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  • Emilsson, Össur IngiDepartment of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden; Faculty of Medicine, University of Iceland, Reykjavik, Iceland (author)

Heritability of cough across two generations : the RHINESSA study.

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • European Respiratory Society,2024
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-536275
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-536275URI
  • https://doi.org/10.1183/23120541.00071-2024DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-229275URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • AIM: Heritability of cough has not yet been studied. We aimed to evaluate if individuals with cough are more likely to have offspring who develop cough, and if these associations differ by type of cough (productive/nonproductive).METHODS: The RHINESSA Generation Study (Respiratory Health In Northern Europe, Spain and Australia) includes 7155 parents (initially aged 30-54) answering detailed questionnaires in 2000 and 2010, and 8176 offspring ≥20 years answering similar questionnaires in 2012-2019. Chronic cough was categorised as productive or nonproductive (dry) cough. Associations between parental and offspring cough were analysed using mixed-effects logistic regression, adjusting for offspring age, sex, body mass index, smoking history, education level, current asthma, rhinitis, nocturnal gastroesophageal reflux; parent sex and smoking history; centre and family.RESULTS: Among parents with nonproductive cough, 11% of their offspring reported nonproductive cough, compared with 7% of offspring to parents without nonproductive cough, adjusted odds ratio (aOR) 1.59 (95% confidence interval 1.20-2.10). Among parents with productive cough, 14% of their offspring reported productive cough, compared with 11% of offspring to parents without productive cough, aOR 1.34 (1.07-1.67). No associations were found between parent productive cough-offspring nonproductive cough, nor between parent nonproductive cough-offspring productive cough.CONCLUSIONS: Parents with chronic cough are more likely to have offspring with chronic cough independent of parental asthma, suggesting cough to be a separate heritable trait. The type of cough is important, as the nonproductive cough in parent associates only with nonproductive cough in offspring, and the same applied for productive cough.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Johansson, HenrikDepartment of Women’s and Children’s Health, Physiotherapy, Uppsala University, Uppsala, Sweden (author)
  • Johannessen, AneDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (author)
  • Janson, ChristerDepartment of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden (author)
  • Palm, AndreasDepartment of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden (author)
  • Franklin, Karl A.Umeå universitet,Institutionen för kirurgisk och perioperativ vetenskap(Swepub:umu)kafr0021 (author)
  • Oudin, AnnaUmeå universitet,Avdelningen för hållbar hälsa(Swepub:umu)anou0004 (author)
  • Gómez Real, FranciscoDepartment of Clinical Science, University of Bergen, Bergen, Norway; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway (author)
  • Holm, MathiasOccupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden (author)
  • Gislason, ThorarinnFaculty of Medicine, University of Iceland, Reykjavik, Iceland; Landspitali University Hospital, Department of Sleep, Reykjavik, Iceland (author)
  • Lindberg, EvaDepartment of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden (author)
  • Jõgi, RainThe Lung Clinic, Tartu University Hospital, Tartu, Estonia (author)
  • Schlünssen, ViviDepartment of Public Health, Research unit for Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark (author)
  • Callejas-González, Francisco JavierServicio De Neumología, Complejo Hospitalario Universitario De Albacete, Albacete, Spain (author)
  • Zhang, JingwenAllergy and Lung Health Unit, School of Population and Global Health, University of Melbourne, Melbourne, Australia (author)
  • Malinovschi, Andrei,1978-Uppsala universitet,Integrativ Fysiologi,Klinisk fysiologi,Lung- allergi- och sömnforskning,Department of Medical Sciences: Clinical Physiology, Uppsala University, Uppsala, Sweden(Swepub:uu)anmal535 (author)
  • Svanes, CecilieDepartment of Occupational Medicine, Haukeland University Hospital, Bergen, Norway; Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (author)
  • Ekström, MagnusDepartment of Respiratory Medicine, Allergology and Palliative Medicine, Institution for Clinical Sciences, Lund University, Lund, Sweden (author)
  • Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden; Faculty of Medicine, University of Iceland, Reykjavik, IcelandDepartment of Women’s and Children’s Health, Physiotherapy, Uppsala University, Uppsala, Sweden (creator_code:org_t)

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  • In:ERJ open research: European Respiratory Society10:42312-0541

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