Potential tissue implants from the networks based on 1,5-dioxepan-2-one and epsilon-caprolactone

• The synthesis and characterization of degradable polymeric networks for biomedical applications was performed. Cross-linked films of poly(epsilon-caprolactone) (PCL) and poly(1,5-dioxepan-2-one) (PDXO) having various mole fractions of monomers and different cross-link densities were successfully prepared using 2,2'-bis-(epsilon-caprolactone-4-yl) propane (BCP) as cross-linking agent. Reaction parameters were carefully examined to optimise, the film-formin.,, conditions. Networks obtained were elastomeric materials. easy to cast and remove from the mould. Effect of CL content and cross-link density on the final properties of the polymer network was evaluated. High CL content or degree of cross-linking led to increase in Young's modulus and decrease in elongation at break. An increase in crystalline domains in films having a higher CL content was observed by optical microscopy. A greater thermal stability was observed in films having a high CL content. The hydrophilicity of the materials could be tailored by changing the CL content. The surface of the films became rougher with higher CL content.

Ämnesord

NATURVETENSKAP  -- Kemi -- Polymerkemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Polymer Chemistry (hsv//eng)

Nyckelord

Characterization

Crosslinking

Degradation

Implants (surgical)

Monomers

Plastic films

Synthesis (chemical)

Tissue

1

5-dioxepan-2-one

Biomedical applications

Cross-linking agents

Organic polymers

Polymer chemistry

Polymerkemi

Publikations- och innehållstyp

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