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Sökning: id:"swepub:oai:DiVA.org:kth-93019" > Impact of ABCB1 Var...

  • Bergmann, Troels K.University of Queensland (författare)

Impact of ABCB1 Variants on Neutrophil Depression : A Pharmacogenomic Study of Paclitaxel in 92 Women with Ovarian Cancer

  • Artikel/kapitelEngelska2012

Förlag, utgivningsår, omfång ...

  • 2011-10-25
  • Wiley,2012
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-93019
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-93019URI
  • https://doi.org/10.1111/j.1742-7843.2011.00802.xDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-76539URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • QC 20120411
  • Funding Agencies|European Commission|LSHC-CT-2007-037665|Swedish Cancer Society||Swedish Medical Society - Linkoping branch||County Council in Ostergotland||Danish Ministry of Interior Affairs and Health|2006-12103-276|Danish Research Agency|271-05-0266|Roche Denmark||Hvidovre, Denmark||
  • The standard treatment for ovarian cancer in advanced stages is post-surgery treatment with taxane-platin chemotherapy. Despite an initial high response rate, most patients eventually relapse. The dose-limiting toxicities of paclitaxel are neutropenia and neuropathy, but the inter-individual variability is large. The aim of this prospective study was to investigate the impact of genetic variants in key drug metabolizing/transporter genes on toxicity and compliance. CYP2C8*3 and three ABCB1 polymorphisms were chosen for primary analysis, and a host of other candidate genes was explored in 92 prospectively recruited Scandinavian Caucasian women with primary ovarian cancer who were treated with paclitaxel and carboplatin. A single investigator assessed the clinical toxicity in 97% of the patients. Patients carrying variant alleles of ABCB1 C3435T experienced more pronounced neutrophil decrease (63%, 72% and 80% for 3435CC, CT and TT, respectively; p-value 0.03). A similar association was found for G2677T /A, p-value 0.02. For C1236T, there was a trend with p-value 0.06. No statistically significant correlations were found for paclitaxel compliance and sensory neuropathy in the primary analysis. Variants in the drug transporter ABCB1 gene are possibly associated with the neutrophil suppressing effect of paclitaxel in patients with ovarian cancer. This finding has implications for the understanding of bone marrow suppression and future tailored chemotherapy.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Brasch-Andersen, CharlotteUniversity of So Denmark (författare)
  • Gréen, HenrikLinköpings universitet,KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,Klinisk farmakologi,Hälsouniversitetet(Swepub:liu)hengr89 (författare)
  • Mirza, Mansoor R.Odense University Hospital (författare)
  • Skougaard, KristinHerlev Hospital (författare)
  • Wihl, JessicaLund Hospital (författare)
  • Keldsen, NinaHerning Hospital (författare)
  • Damkier, PerOdense University Hospital (författare)
  • Peterson, CurtÖstergötlands Läns Landsting,Linköpings universitet,Klinisk farmakologi,Hälsouniversitetet,Onkologiska kliniken US(Swepub:liu)curpe13 (författare)
  • Vach, WernerInstitute Medical Biometry and Medical Informat, Freiburg (författare)
  • Brosen, KimUniversity of So Denmark (författare)
  • University of QueenslandUniversity of So Denmark (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Basic & Clinical Pharmacology & Toxicology: Wiley110:2, s. 199-2041742-78351742-7843

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