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The Use of Central ...
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Källén, BengtLund University,Lunds universitet,Tornbladinstitutet,Forskargrupper vid Lunds universitet,Tornblad Institute,Lund University Research Groups,Tornblad Institute, Lund Univeraity, Sweden
(author)
The Use of Central Nervous System Active Drugs During Pregnancy
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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2013-10-10
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MDPI AG,2013
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-100125
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-100125URI
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https://doi.org/10.3390/ph6101221DOI
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https://lup.lub.lu.se/record/4178927URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:for swepub-publicationtype
Notes
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CNS-active drugs are used relatively often during pregnancy. Use during early pregnancy may increase the risk of a congenital malformation; use during the later part of pregnancy may be associated with preterm birth, intrauterine growth disturbances and neonatal morbidity. There is also a possibility that drug exposure can affect brain development with long-term neuropsychological harm as a result. This paper summarizes the literature on such drugs used during pregnancy: opioids, anticonvulsants, drugs used for Parkinson’s disease, neuroleptics, sedatives and hypnotics, antidepressants, psychostimulants, and some other CNS-active drugs. In addition to an overview of the literature, data from the Swedish Medical Birth Register (1996–2011) are presented. The exposure data are either based on midwife interviews towards the end of the first trimester or on linkage with a prescribed drug register. An association between malformations and maternal use of anticonvulsants and notably valproic acid is well known from the literature and also demonstrated in the present study. Some other associations between drug exposure and outcome were found.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Borg, NataliaDepartment of Statistics, Monitoring and Analyses, National Board of Health and Welfare, Sweden
(author)
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Reis, MargaretaLund University,Lunds universitet,Linköpings universitet,Avdelningen för läkemedelsforskning,Hälsouniversitetet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)klin-mre
(author)
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TornbladinstitutetForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
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In:Pharmaceuticals: MDPI AG6:10, s. 1221-12861424-8247
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