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  • Källén, BengtLund University,Lunds universitet,Tornbladinstitutet,Forskargrupper vid Lunds universitet,Tornblad Institute,Lund University Research Groups,Tornblad Institute, Lund Univeraity, Sweden (author)

The Use of Central Nervous System Active Drugs During Pregnancy

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2013-10-10
  • MDPI AG,2013
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-100125
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-100125URI
  • https://doi.org/10.3390/ph6101221DOI
  • https://lup.lub.lu.se/record/4178927URI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:for swepub-publicationtype

Notes

  • CNS-active drugs are used relatively often during pregnancy. Use during early pregnancy may increase the risk of a congenital malformation; use during the later part of pregnancy may be associated with preterm birth, intrauterine growth disturbances and neonatal morbidity. There is also a possibility that drug exposure can affect brain development with long-term neuropsychological harm as a result. This paper summarizes the literature on such drugs used during pregnancy: opioids, anticonvulsants, drugs used for Parkinson’s disease, neuroleptics, sedatives and hypnotics, antidepressants, psychostimulants, and some other CNS-active drugs. In addition to an overview of the literature, data from the Swedish Medical Birth Register (1996–2011) are presented. The exposure data are either based on midwife interviews towards the end of the first trimester or on linkage with a prescribed drug register. An association between malformations and maternal use of anticonvulsants and notably valproic acid is well known from the literature and also demonstrated in the present study. Some other associations between drug exposure and outcome were found.

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  • Borg, NataliaDepartment of Statistics, Monitoring and Analyses, National Board of Health and Welfare, Sweden (author)
  • Reis, MargaretaLund University,Lunds universitet,Linköpings universitet,Avdelningen för läkemedelsforskning,Hälsouniversitetet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)klin-mre (author)
  • TornbladinstitutetForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Pharmaceuticals: MDPI AG6:10, s. 1221-12861424-8247

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By the author/editor
Källén, Bengt
Borg, Natalia
Reis, Margareta
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Pharmaceutical S ...
Articles in the publication
Pharmaceuticals
By the university
Linköping University
Lund University

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