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Salt-inducible kina...
Salt-inducible kinase 1 influences Na+,K+-ATPase activity in vascular smooth muscle cells and associates with variations in blood pressure
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- Popov, Sergej (author)
- Karolinska Institutet
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- Silveira, Angela (author)
- Karolinska Institutet
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- Wågsäter, Dick (author)
- Karolinska University Hospital, Solna, Stockholm, Sweden
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- Takemori, Hiroshi (author)
- National Institute for Biomedical Innovation, Osaka, Japan
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- Oguro, Ryousuke (author)
- Osaka University, Japan
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- Matsumoto, Sachiko (author)
- National Cerebral and Cardiovascular Center, Suita, Japan
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- Sugimoto, Ken (author)
- Osaka University, Japan
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- Kamide, Kei (author)
- Osaka University, Japan
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- Hirose, Takuo (author)
- Tohoku University, Sendai, Japan
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- Satoh, Michihiro (author)
- Tohoku University, Sendai, Japan
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- Metoki, Hirohito (author)
- Tohoku University, Sendai, Japan
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- Kikuya, Masahiro (author)
- Tohoku University, Sendai, Japan
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- Ohkubo, Takayoshi (author)
- Tohoku University, Sendai, Japan
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- Katsuya, Tomohiro (author)
- Osaka University, Japan
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- Rakugi, Hiromi (author)
- Osaka University, Japan
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- Imai, Yutaka (author)
- Tohoku University, Sendai, Japan
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- Sanchez, Fabio (author)
- Karolinska University Hospital, Solna, Stockholm, Sweden
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- Leosdottir, Margrét (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Lund University, Sweden
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- Syvänen, Ann-Christine (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala University, Sweden
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- Hamsten, Anders (author)
- Karolinska Institutet
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Lund University, Sweden
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- Bertorello, Alejandro M. (author)
- Karolinska Institutet
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2011
- 2011
- English.
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In: Journal of Hypertension. - : Lippincott Williams & Wilkins. - 0263-6352 .- 1473-5598. ; 29:12, s. 2395-2403
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
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- OBJECTIVES:Essential hypertension is a complex condition whose cause involves the interaction of multiple genetic and environmental factors such as salt intake. Salt-inducible kinase 1 (SIK1) is a sucrose-nonfermenting-like kinase isoform that belongs to the AMPK (5' adenosine monophosphate-activated protein kinase) family. SIK1 activity is increased by high salt intake and plays an essential role in regulating the plasma membrane Na(+),K(+)-ATPase. The objective of this study was to examine whether SIK1 is present in vascular smooth muscle cells (VSMCs) and endothelial cells, whether it affects VSMC Na(+),K(+)-ATPase activity and whether human SIK1 (hSIK1) represents a potential candidate for blood pressure regulation.METHODS:Localization of SIK1 was performed using immunohistochemistry, mRNA and western blot. Functional assays (Na(+),K(+)-ATPase activity) were performed in VSMCs derived from rat aorta. Genotype-phenotype association studies were performed in three Swedish and one Japanese population-based cohorts.RESULTS:SIK1 was localized in human VSMCs and endothelial cells, as well as a cell line derived from rat aorta. A nonsynonymous single nucleotide polymorphism in the hSIK1 gene exon 3 (C→T, rs3746951) results in the amino acid change (15)Gly→Ser in the SIK1 protein. SIK1-(15)Ser was found to increase plasma membrane Na(+),K(+)-ATPase activity in cultured VSMC line from rat aorta. Genotype-phenotype association studies in three Swedish and one Japanese population-based cohorts suggested that T allele (coding for (15)Ser) was associated with lower blood pressure (P = 0.005 for SBP and P = 0.002 for DBP) and with a decrease in left ventricular mass (P = 0.048).CONCLUSION:The hSIK1 appears to be of potential relevance within VSMC function and blood pressure regulation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- hypertension; Na
- K+-ATPase; salt sensitivity; vascular tonus
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Popov, Sergej
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Silveira, Angela
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Wågsäter, Dick
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Takemori, Hirosh ...
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Oguro, Ryousuke
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Matsumoto, Sachi ...
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show more...
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Sugimoto, Ken
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Kamide, Kei
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Hirose, Takuo
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Satoh, Michihiro
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Metoki, Hirohito
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Kikuya, Masahiro
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Ohkubo, Takayosh ...
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Katsuya, Tomohir ...
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Rakugi, Hiromi
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Imai, Yutaka
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Sanchez, Fabio
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Leosdottir, Marg ...
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Syvänen, Ann-Chr ...
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Hamsten, Anders
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Melander, Olle
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Bertorello, Alej ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Journal of Hyper ...
- By the university
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Linköping University
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Uppsala University
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Lund University
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Karolinska Institutet