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Salt-inducible kina...
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Popov, SergejKarolinska Institutet
(författare)
Salt-inducible kinase 1 influences Na+,K+-ATPase activity in vascular smooth muscle cells and associates with variations in blood pressure
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
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Lippincott Williams & Wilkins,2011
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-100331
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-100331URI
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https://doi.org/10.1097/HJH.0b013e32834d3d55DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-162973URI
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https://lup.lub.lu.se/record/2221263URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:123595166URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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OBJECTIVES:Essential hypertension is a complex condition whose cause involves the interaction of multiple genetic and environmental factors such as salt intake. Salt-inducible kinase 1 (SIK1) is a sucrose-nonfermenting-like kinase isoform that belongs to the AMPK (5' adenosine monophosphate-activated protein kinase) family. SIK1 activity is increased by high salt intake and plays an essential role in regulating the plasma membrane Na(+),K(+)-ATPase. The objective of this study was to examine whether SIK1 is present in vascular smooth muscle cells (VSMCs) and endothelial cells, whether it affects VSMC Na(+),K(+)-ATPase activity and whether human SIK1 (hSIK1) represents a potential candidate for blood pressure regulation.METHODS:Localization of SIK1 was performed using immunohistochemistry, mRNA and western blot. Functional assays (Na(+),K(+)-ATPase activity) were performed in VSMCs derived from rat aorta. Genotype-phenotype association studies were performed in three Swedish and one Japanese population-based cohorts.RESULTS:SIK1 was localized in human VSMCs and endothelial cells, as well as a cell line derived from rat aorta. A nonsynonymous single nucleotide polymorphism in the hSIK1 gene exon 3 (C→T, rs3746951) results in the amino acid change (15)Gly→Ser in the SIK1 protein. SIK1-(15)Ser was found to increase plasma membrane Na(+),K(+)-ATPase activity in cultured VSMC line from rat aorta. Genotype-phenotype association studies in three Swedish and one Japanese population-based cohorts suggested that T allele (coding for (15)Ser) was associated with lower blood pressure (P = 0.005 for SBP and P = 0.002 for DBP) and with a decrease in left ventricular mass (P = 0.048).CONCLUSION:The hSIK1 appears to be of potential relevance within VSMC function and blood pressure regulation.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Silveira, AngelaKarolinska Institutet
(författare)
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Wågsäter, DickKarolinska University Hospital, Solna, Stockholm, Sweden(Swepub:liu)dicwa60
(författare)
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Takemori, HiroshiNational Institute for Biomedical Innovation, Osaka, Japan
(författare)
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Oguro, RyousukeOsaka University, Japan
(författare)
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Matsumoto, SachikoNational Cerebral and Cardiovascular Center, Suita, Japan
(författare)
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Sugimoto, KenOsaka University, Japan
(författare)
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Kamide, KeiOsaka University, Japan
(författare)
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Hirose, TakuoTohoku University, Sendai, Japan
(författare)
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Satoh, MichihiroTohoku University, Sendai, Japan
(författare)
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Metoki, HirohitoTohoku University, Sendai, Japan
(författare)
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Kikuya, MasahiroTohoku University, Sendai, Japan
(författare)
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Ohkubo, TakayoshiTohoku University, Sendai, Japan
(författare)
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Katsuya, TomohiroOsaka University, Japan
(författare)
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Rakugi, HiromiOsaka University, Japan
(författare)
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Imai, YutakaTohoku University, Sendai, Japan
(författare)
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Sanchez, FabioKarolinska University Hospital, Solna, Stockholm, Sweden
(författare)
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Leosdottir, MargrétLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Lund University, Sweden(Swepub:lu)medf-mle
(författare)
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Syvänen, Ann-ChristineUppsala universitet,Institutionen för medicinska vetenskaper,Uppsala University, Sweden(Swepub:uu)anncsyva
(författare)
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Hamsten, AndersKarolinska Institutet
(författare)
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Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Lund University, Sweden(Swepub:lu)endo-ome
(författare)
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Bertorello, Alejandro M.Karolinska Institutet
(författare)
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Karolinska InstitutetKarolinska University Hospital, Solna, Stockholm, Sweden
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Hypertension: Lippincott Williams & Wilkins29:12, s. 2395-24030263-63521473-5598
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Till lärosätets databas
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Popov, Sergej
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Silveira, Angela
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Wågsäter, Dick
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Takemori, Hirosh ...
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Oguro, Ryousuke
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Matsumoto, Sachi ...
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visa fler...
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Sugimoto, Ken
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Kamide, Kei
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Hirose, Takuo
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Satoh, Michihiro
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Metoki, Hirohito
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Kikuya, Masahiro
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Ohkubo, Takayosh ...
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Katsuya, Tomohir ...
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Rakugi, Hiromi
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Imai, Yutaka
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Sanchez, Fabio
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Leosdottir, Marg ...
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Syvänen, Ann-Chr ...
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Hamsten, Anders
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Melander, Olle
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Bertorello, Alej ...
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och Klinisk medicin
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