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Viscoelastic and hi...
Viscoelastic and histologic properties in scarred rabbit vocal folds after mesenchymal stem cell injection
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- Hertegard, S. (author)
- Karolinska Institutet
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- Cedervall, J. (author)
- Karolinska Institutet, Stockholm, Sweden
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- Svensson, B. (author)
- Karolinska Institutet
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- Forsberg, K. (author)
- University of Umeå, Sweden
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- Maurer, Frans (author)
- Lund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Lund University, Sweden
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- Vidovska, Daniela (author)
- Lund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Lund University, Sweden;
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- Olivius, Petri (author)
- Karolinska Institutet
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- Ährlund-Richter, L. (author)
- Karolinska Institutet
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- Le Blanc, K. (author)
- Karolinska Institutet
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- Forsgren, Kristina (author)
- Umeå universitet,Öron- näs- och halssjukdomar
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(creator_code:org_t)
- Wiley-Blackwell, 2006
- 2006
- English.
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In: The Laryngoscope. - : Wiley-Blackwell. - 0023-852X .- 1531-4995. ; 116:7, s. 1248-1254
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Abstract
Subject headings
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- OBJECTIVE/HYPOTHESIS:The aim of this study was to analyze the short-term viscoelastic and histologic properties of scarred rabbit vocal folds after injection of human mesenchymal stem cells (MSC) as well as the degree of MSC survival. Because MSCs are antiinflammatory and regenerate mesenchymal tissues, can MSC injection reduce vocal fold scarring after injury?STUDY DESIGN:Twelve vocal folds from 10 New Zealand rabbits were scarred by a localized resection and injected with human MSC or saline. Eight vocal folds were left as controls.MATERIAL AND METHODS:After 4 weeks, 10 larynges were stained for histology and evaluation of the lamina propria thickness. Collagen type I content was analyzed from six rabbits. MSC survival was analyzed by fluorescent in situ hybridization staining from three rabbits. Viscoelasticity for 10 vocal folds was analyzed in a parallel-plate rheometer.RESULTS:The rheometry on fresh-frozen samples showed decreased dynamic viscosity and lower elastic modulus (P<.01) in the scarred samples injected with MSC as compared with the untreated scarred group. Normal controls had lower dynamic viscosity and elastic modulus as compared with the scarred untreated and treated vocal folds (P<.01). Histologic analysis showed a higher content of collagen type 1 in the scarred samples as compared with the normal vocal folds and with the scarred folds treated with MSC. MSCs remained in all samples analyzed.CONCLUSIONS:The treated scarred vocal folds showed persistent MSC. Injection of scarred rabbit vocal folds with MSC rendered improved viscoelastic parameters and less signs of scarring expressed as collagen content in comparison to the untreated scarred vocal folds.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- vocal fold scarring; vocal fold; viscoelasticity; mesenchymal stem cells
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hertegard, S.
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Cedervall, J.
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Svensson, B.
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Forsberg, K.
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Maurer, Frans
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Vidovska, Daniel ...
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show more...
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Olivius, Petri
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Ährlund-Richter, ...
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Le Blanc, K.
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Forsgren, Kristi ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
- Articles in the publication
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The Laryngoscope
- By the university
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Linköping University
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Lund University
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Karolinska Institutet
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Umeå University