Search: L773:0031 6768 OR L773:1432 2013
> (2010-2014) >
Noise-induced alter...
-
Jacob, StefanKarolinska Institutet,Karolinska Institutet, Stockholm, Sweden
(author)
Noise-induced alterations in cochlear mechanics, electromotility, and cochlear amplification
- Article/chapterEnglish2013
Publisher, publication year, extent ...
-
2012-12-18
-
Springer,2013
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:liu-101046
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-101046URI
-
https://doi.org/10.1007/s00424-012-1198-4DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:126839092URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Loud sounds are a common cause of hearing loss. Very intense sounds may result in permanent hearing loss, but lower levels typically cause a transient decrease in auditory sensitivity. Studies have arrived at different conclusions as regards the physiological mechanisms underlying such temporary threshold shifts. Here, we investigated the effect of acoustic overstimulation on the mechanics of the low-frequency areas of the guinea pig cochlea. We demonstrate that brief loud sound exposure results in an increased phase lag and a paradoxical frequency-specific increase of sound-evoked displacement. Despite the increased displacement, electrically evoked motion is reduced. Because electromotility is important for amplifying low-level sounds, this change was associated with a decrease in measures of cochlear amplification. These changes recovered over the course of 30-40 min. Overstimulation also caused an increase in cytoplasmic calcium levels of both hair cells and supporting cells. These data suggest that reduced organ of Corti stiffness contributes to temporary threshold shifts.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Johansson, CeciliaKarolinska Institutet, Stockholm, Sweden
(author)
-
Fridberger, Anders,1966-Karolinska Institutet, Stockholm, Sweden(Swepub:liu)andfr39
(author)
-
Karolinska InstitutetKarolinska Institutet, Stockholm, Sweden
(creator_code:org_t)
Related titles
-
In:Pflügers Archiv: Springer465:6, s. 907-9170031-67681432-2013
Internet link
Find in a library
To the university's database