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  • Nordmark, GunnelUppsala universitet,Reumatologi,Uppsala University, Sweden (author)

Association of Genes in the NF-κB Pathway with Antibody-Positive Primary Sjögren's Syndrome

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2013-10-27
  • Wiley-Blackwell,2013
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-101382
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-101382URI
  • https://doi.org/10.1111/sji.12101DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-102963URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-207900URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:127649636URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Knut and Alice Wallenberg Foundation||Swedish Research Council for Medicine and Health||Swedish Rheumatism Association||King Gustaf V 80-year Foundation||County Council of ostergotland and Linkoping University Hospital||Health and Medical Care Executive Board of the Vastra Gotaland||Medical Society of Goteborg and the Region Vastra Gotaland||Strategic Research Program at Helse Bergen||Western Norway Regional Health Authority||Broegelmann Foundation||Medical Research Council UK||
  • Primary Sjogrens syndrome (SS) is a systemic autoimmune inflammatory disease characterized by focal lymphocytic infiltrates in the lachrymal and salivary glands and autoantibodies against the SSA/Ro and SSB/La antigens. Experimental studies have shown an activation of NF-B in primary SS. NF-B activation results in inflammation and autoimmunity and is regulated by inhibitory and activating proteins. Genetic studies have shown an association between multiple autoimmune diseases and TNFAIP3 (A20) and TNIP1 (ABIN1), both repressors of NF-B and of IKBKE (IKK epsilon), which is an NF-B activator. The aim of this study was to analyse single nucleotide polymorphisms (SNPs) in the IKBKE, NFKB1, TNIP1 and TNFAIP3 genes for association with primary SS. A total of 12 SNPs were genotyped in 1105 patients from Scandinavia (Sweden and Norway, n=684) and the UK (n=421) and 4460 controls (Scandinavia, n=1662, UK, n=2798). When patients were stratified for the presence of anti-SSA and/or anti-SSB antibodies (n=868), case-control meta-analysis found an association between antibody-positive primary SS and two SNPs in TNIP1 (P=3.4x10(-5), OR=1.33, 95%CI: 1.16-1.52 for rs3792783 and P=1.3x10(-3), OR=1.21, 95%CI: 1.08-1.36 for rs7708392). A TNIP1 risk haplotype was associated with antibody-positive primary SS (P=5.7x10(-3), OR=1.47, 95%CI: 1.12-1.92). There were no significant associations with IKBKE, NFKB1 or TNFAIP3 in the meta-analysis of the Scandinavian and UK cohorts. We conclude that polymorphisms in TNIP1 are associated with antibody-positive primary SS.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Wang, ChuanUppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab,Uppsala University, Sweden(Swepub:uu)chuwa904 (author)
  • Vasaitis, LilianUppsala universitet,Reumatologi,Uppsala University, Sweden(Swepub:uu)lilva850 (author)
  • Eriksson, PerÖstergötlands Läns Landsting,Linköpings universitet,Reumatologi,Hälsouniversitetet,Reumatologiska kliniken i Östergötland(Swepub:liu)perer22 (author)
  • Theander, ElkeLund University, Sweden (author)
  • Kvarnström, MarikaKarolinska Institutet (author)
  • Forsblad-d'Elia, HelenaUniversity of Gothenburg, Sweden,Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg(Swepub:umu)hefo0034 (author)
  • Jazebi, HelmiKarolinska Institutet, Stockholm, Sweden (author)
  • Sjöwall, ChristofferÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för inflammationsmedicin,Hälsouniversitetet,Reumatologiska kliniken i Östergötland(Swepub:liu)chrsj93 (author)
  • Reksten, Tove RagnaUniversity of Bergen, Norway (author)
  • Brun, Johan G.Haukeland University Hospital, Bergen, Norway (author)
  • Jonsson, Malin V.University of Bergen, Norway (author)
  • Johnsen, Svein J.Stavanger University Hospital, Norway (author)
  • Wahren-Herlenius, MarieKarolinska Institutet (author)
  • Omdal, RoaldStavanger University Hospital, Norway (author)
  • Jonsson, RolandUniversity of Bergen, Norway (author)
  • Bowman, SimonUniversity Hospital Birmingham, UK (author)
  • Ng, Wan-FaiNewcastle University, UK (author)
  • Eloranta, Maija-LeenaUppsala universitet,Reumatologi,Uppsala University, Sweden(Swepub:uu)maelo020 (author)
  • Syvänen, Ann-ChristineUppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab,Uppsala University, Sweden(Swepub:uu)anncsyva (author)
  • Uppsala universitetReumatologi (creator_code:org_t)

Related titles

  • In:Scandinavian Journal of Immunology: Wiley-Blackwell78:5, s. 447-4540300-94751365-3083

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