Search: id:"swepub:oai:DiVA.org:liu-101394" >
Cold Exposure Promo...
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Dong, MeiShandong University, Peoples R China
(author)
Cold Exposure Promotes Atherosclerotic Plaque Growth and Instability via UCP1-Dependent Lipolysis
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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Elsevier (Cell Press),2013
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-101394
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-101394URI
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https://doi.org/10.1016/j.cmet.2013.06.003DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:127623600URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Swedish Research Council||Swedish Cancer Foundation||Karolinska Institute Foundation||Karolinska Institute Distinguished Professor Award||Torsten Soderbergs Foundation||Tianjin Natural Science Foundation (CMM-Tianjin)|09ZCZDSF04400|ImClone Systems of Eli Lilly||European Union Integrated Project of Metoxia|222741|European Research Council (ERC) advanced grant ANGIOFAT|250021|National 973 Basic Research Program of China|2011CB5039062012CB518603|National High-Tech Research and Development Program of China|2012AA02A510|Program of Introducing Talents of Discipline to Universities|B07035|State Program of National Natural Science Foundation of China for Innovative Research Group|81021001|National Natural Science Foundation of China|811002078117325181100102812703508100012681000127|
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Molecular mechanisms underlying the cold-associated high cardiovascular risk remain unknown. Here, we show that the cold-triggered food-intake-independent lipolysis significantly increased plasma levels of small low-density lipoprotein (LDL) remnants, leading to accelerated development of atherosclerotic lesions in mice. In two genetic mouse knockout models (apolipoprotein E-/- [ApoE(-/-)] and LDL receptor(-/-) [Ldlr(-/-)] mice), persistent cold exposure stimulated atherosclerotic plaque growth by increasing lipid deposition. Furthermore, marked increase of inflammatory cells and plaque-associated microvessels were detected in the cold-acclimated ApoE(-/-) and Ldlr(-/-) mice, leading to plaque instability. Deletion of uncoupling protein 1 (UCP1), a key mitochondrial protein involved in thermogenesis in brown adipose tissue (BAT), in the ApoE(-/-) strain completely protected mice from the cold-induced atherosclerotic lesions. Cold acclimation markedly reduced plasma levels of adiponectin, and systemic delivery of adiponectin protected ApoE(-/-) mice from plaque development. These findings provide mechanistic insights on low-temperature-associated cardiovascular risks.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Yang, XiaoyanShandong University, Peoples R China
(author)
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Lim, SharonKarolinska Institutet
(author)
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Cao, ZiquanLinköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet(Swepub:liu)ziqca08
(author)
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Honek, JenniferKarolinska Institutet
(author)
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Lu, HuixiaShandong University, Peoples R China
(author)
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Zhang, ChengShandong University, Peoples R China
(author)
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Seki, TakahiroKarolinska Institutet
(author)
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Hosaka, KayokoKarolinska Institutet
(author)
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Wahlberg, EricÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Thorax-kärlkliniken i Östergötland(Swepub:liu)eriwa73
(author)
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Yang, JianminShandong University, Peoples R China
(author)
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Zhang, LeiShandong University, Peoples R China
(author)
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Länne, TosteÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Thorax-kärlkliniken i Östergötland(Swepub:liu)tosla34
(author)
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Sun, BaocunTianjin Medical University, Peoples R China
(author)
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Li, XuriSun Yat Sen University, Peoples R China
(author)
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Liu, YizhiSun Yat Sen University, Peoples R China
(author)
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Zhang, YunShandong University, Peoples R China
(author)
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Cao, YihaiKarolinska Institutet
(author)
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Karolinska InstitutetShandong University, Peoples R China
(creator_code:org_t)
Related titles
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In:Cell Metabolism: Elsevier (Cell Press)18:1, s. 118-1291550-41311932-7420
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- By the author/editor
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Dong, Mei
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Yang, Xiaoyan
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Lim, Sharon
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Cao, Ziquan
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Honek, Jennifer
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Lu, Huixia
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show more...
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Zhang, Cheng
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Seki, Takahiro
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Hosaka, Kayoko
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Wahlberg, Eric
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Yang, Jianmin
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Zhang, Lei
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Länne, Toste
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Sun, Baocun
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Li, Xuri
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Liu, Yizhi
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Zhang, Yun
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Cao, Yihai
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- Articles in the publication
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Cell Metabolism
- By the university
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Linköping University
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Karolinska Institutet