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Contribution of the N-acetyltransferase 2 polymorphism NAT2*6A to age-related hearing impairment

Van Eyken, Els (author)
Department of Medical Genetics, University of Antwerp (UA), Antwerp, Belgium
Van Camp, Guy (author)
Department of Medical Genetics, University of Antwerp (UA), Antwerp, Belgium
Fransen, Erik (author)
Department of Medical Genetics, University of Antwerp (UA), Antwerp, Belgium
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Topsakal, Vedat (author)
Department of Otorhinolaryngology, University Hospital of Antwerp (UZA), Antwerp, Belgium
Henricxk, Jan-Jaap (author)
Department of Otorhinolaryngology, University Hospital of Antwerp (UZA), Antwerp, Belgium
Demeester, Kelly (author)
Department of Otorhinolaryngology, University Hospital of Antwerp (UZA), Antwerp, Belgium
Van de Heyning, Paul (author)
Department of Otorhinolaryngology, University Hospital of Antwerp (UZA), Antwerp, Belgium
Mäki-Torkko, Elina (author)
Örebro universitet,Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Öronkliniken US,Department of Otorhinolaryngology, University of Oulu, Oulu, Finland,Institutionen för medicinska vetenskaper
Hannula, Samuli (author)
Department of Otorhinolaryngology, University of Oulu, Oulu, Finland
Sorri, Martti (author)
Department of Otorhinolaryngology, University of Oulu, Oulu, Finland
Jensen, Mona (author)
Department of Audiology, Bispebjerg Hospital (BBH), Copenhagen, Denmark
Parving, Agnete (author)
Department of Audiology, Bispebjerg Hospital (BBH), Copenhagen, Denmark
Bille, Mikael (author)
Department of Audiology, Bispebjerg Hospital (BBH), Copenhagen, Denmark
Baur, Manuela (author)
Department of Otorhinolaryngology, University of Tuebingen, Tuebingen, Germany
Pfister, Markus (author)
Department of Otorhinolaryngology, University of Tuebingen, Tuebingen, Germany
Bonaconsa, Amanda (author)
Department of Oto-surgery, University Hospital Padova, Padova, Italy
Mazzoli, Manuela (author)
Department of Oto-surgery, University Hospital Padova, Padova, Italy,Department of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
Orzan, Eva (author)
Department of Oto-surgery, University Hospital Padova, Padova, Italy
Espeso, Angeles (author)
Welsh hearing Institute, University Hospital of Wales, Cardiff, UK
Stephens, Dafydd (author)
Welsh hearing Institute, University Hospital of Wales, Cardiff, UK
Verbruggen, Katia (author)
Department of Otorhinolaryngology, University Hospital of Gent (UZ), Gent, Belgium
Huyghe, Joke (author)
Department of Otorhinolaryngology, University Hospital of Gent (UZ), Gent, Belgium
Dhooge, Ingeborg (author)
Department of Otorhinolaryngology, University Hospital of Gent (UZ), Gent, Belgium
Huygen, Patrick (author)
Radboud University Nijmegen Medical Centre, the Netherlands
Kremer, Hannie (author)
Department of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
Cremers, Cor (author)
Department of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
Kunst, Sylvia (author)
Department of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
Manninen, Minna (author)
Department of Otorhinolaryngology, University of Tampere, Tampere, Finland
Pyykkö, Ilmari (author)
Department of Otorhinolaryngology, University of Tampere, Tampere, Finland
Lacava, A. (author)
Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany
Steffens, Michael (author)
Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany
Wienker, Thomas (author)
Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany
Van Laer, Lut (author)
Department of Medical Genetics, University of Antwerp (UA), Antwerp, Belgium
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 (creator_code:org_t)
2007-05-11
2007
English.
In: Journal of Medical Genetics. - : B M J Group. - 0022-2593 .- 1468-6244. ; 44:9, s. 570-578
Related links:
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https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • BackgroundAge‐related hearing impairment (ARHI) is the most common sensory impairment in older people, affecting 50% of those aged 80 years. The proportion of older people is increasing in the general population, and as a consequence, the number of people affected with ARHI is growing. ARHI is a complex disorder, with both environmental and genetic factors contributing to the disease. The first studies to elucidate these genetic factors were recently performed, resulting in the identification of the first two susceptibility genes for ARHI, NAT2 and KCNQ4.MethodsIn the present study, the association between ARHI and polymorphisms in genes that contribute to the defence against reactive oxygen species, including GSTT1, GSTM1 and NAT2, was tested. Samples originated from seven different countries and were combined into two test population samples, the general European population and the Finnish population. Two distinct phenotypes for ARHI were studied, Zlow and Zhigh, representing hearing in the low and high frequencies, respectively. Statistical analysis was performed for single polymorphisms (GSTM1, GSTT1, NAT2*5A, NAT2*6A, and NAT2*7A), haplotypes, and gene–environment and gene–gene interactions.ResultsWe found an association between ARHI and GSTT1 and GSTM1 in the Finnish population sample, and with NAT2*6A in the general European population sample. The latter finding replicates previously published data.ConclusionAs replication is considered the ultimate proof of true associations in the study of complex disorders, this study provides further support for the involvement of NAT2*6A in ARHI.                 

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)

Keyword

N‐acetyltransferase
age related hearing impairment
association study
complex disorder
glutathione S‐transferase

Publication and Content Type

ref (subject category)
art (subject category)

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