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  • Van Eyken, ElsDepartment of Medical Genetics, University of Antwerp (UA), Antwerp, Belgium (författare)

Contribution of the N-acetyltransferase 2 polymorphism NAT2*6A to age-related hearing impairment

  • Artikel/kapitelEngelska2007

Förlag, utgivningsår, omfång ...

  • 2007-05-11
  • B M J Group,2007
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-101413
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-101413URI
  • https://doi.org/10.1136/jmg.2007.049205DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-63475URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BackgroundAge‐related hearing impairment (ARHI) is the most common sensory impairment in older people, affecting 50% of those aged 80 years. The proportion of older people is increasing in the general population, and as a consequence, the number of people affected with ARHI is growing. ARHI is a complex disorder, with both environmental and genetic factors contributing to the disease. The first studies to elucidate these genetic factors were recently performed, resulting in the identification of the first two susceptibility genes for ARHI, NAT2 and KCNQ4.MethodsIn the present study, the association between ARHI and polymorphisms in genes that contribute to the defence against reactive oxygen species, including GSTT1, GSTM1 and NAT2, was tested. Samples originated from seven different countries and were combined into two test population samples, the general European population and the Finnish population. Two distinct phenotypes for ARHI were studied, Zlow and Zhigh, representing hearing in the low and high frequencies, respectively. Statistical analysis was performed for single polymorphisms (GSTM1, GSTT1, NAT2*5A, NAT2*6A, and NAT2*7A), haplotypes, and gene–environment and gene–gene interactions.ResultsWe found an association between ARHI and GSTT1 and GSTM1 in the Finnish population sample, and with NAT2*6A in the general European population sample. The latter finding replicates previously published data.ConclusionAs replication is considered the ultimate proof of true associations in the study of complex disorders, this study provides further support for the involvement of NAT2*6A in ARHI.                 

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Van Camp, GuyDepartment of Medical Genetics, University of Antwerp (UA), Antwerp, Belgium (författare)
  • Fransen, ErikDepartment of Medical Genetics, University of Antwerp (UA), Antwerp, Belgium (författare)
  • Topsakal, VedatDepartment of Otorhinolaryngology, University Hospital of Antwerp (UZA), Antwerp, Belgium (författare)
  • Henricxk, Jan-JaapDepartment of Otorhinolaryngology, University Hospital of Antwerp (UZA), Antwerp, Belgium (författare)
  • Demeester, KellyDepartment of Otorhinolaryngology, University Hospital of Antwerp (UZA), Antwerp, Belgium (författare)
  • Van de Heyning, PaulDepartment of Otorhinolaryngology, University Hospital of Antwerp (UZA), Antwerp, Belgium (författare)
  • Mäki-Torkko, ElinaÖrebro universitet,Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Öronkliniken US,Department of Otorhinolaryngology, University of Oulu, Oulu, Finland,Institutionen för medicinska vetenskaper(Swepub:oru)emo (författare)
  • Hannula, SamuliDepartment of Otorhinolaryngology, University of Oulu, Oulu, Finland (författare)
  • Sorri, MarttiDepartment of Otorhinolaryngology, University of Oulu, Oulu, Finland (författare)
  • Jensen, MonaDepartment of Audiology, Bispebjerg Hospital (BBH), Copenhagen, Denmark (författare)
  • Parving, AgneteDepartment of Audiology, Bispebjerg Hospital (BBH), Copenhagen, Denmark (författare)
  • Bille, MikaelDepartment of Audiology, Bispebjerg Hospital (BBH), Copenhagen, Denmark (författare)
  • Baur, ManuelaDepartment of Otorhinolaryngology, University of Tuebingen, Tuebingen, Germany (författare)
  • Pfister, MarkusDepartment of Otorhinolaryngology, University of Tuebingen, Tuebingen, Germany (författare)
  • Bonaconsa, AmandaDepartment of Oto-surgery, University Hospital Padova, Padova, Italy (författare)
  • Mazzoli, ManuelaDepartment of Oto-surgery, University Hospital Padova, Padova, Italy,Department of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands (författare)
  • Orzan, EvaDepartment of Oto-surgery, University Hospital Padova, Padova, Italy (författare)
  • Espeso, AngelesWelsh hearing Institute, University Hospital of Wales, Cardiff, UK (författare)
  • Stephens, DafyddWelsh hearing Institute, University Hospital of Wales, Cardiff, UK (författare)
  • Verbruggen, KatiaDepartment of Otorhinolaryngology, University Hospital of Gent (UZ), Gent, Belgium (författare)
  • Huyghe, JokeDepartment of Otorhinolaryngology, University Hospital of Gent (UZ), Gent, Belgium (författare)
  • Dhooge, IngeborgDepartment of Otorhinolaryngology, University Hospital of Gent (UZ), Gent, Belgium (författare)
  • Huygen, PatrickRadboud University Nijmegen Medical Centre, the Netherlands (författare)
  • Kremer, HannieDepartment of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands (författare)
  • Cremers, CorDepartment of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands (författare)
  • Kunst, SylviaDepartment of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands (författare)
  • Manninen, MinnaDepartment of Otorhinolaryngology, University of Tampere, Tampere, Finland (författare)
  • Pyykkö, IlmariDepartment of Otorhinolaryngology, University of Tampere, Tampere, Finland (författare)
  • Lacava, A.Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany (författare)
  • Steffens, MichaelInstitute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany (författare)
  • Wienker, ThomasInstitute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany (författare)
  • Van Laer, LutDepartment of Medical Genetics, University of Antwerp (UA), Antwerp, Belgium (författare)
  • Department of Medical Genetics, University of Antwerp (UA), Antwerp, BelgiumDepartment of Otorhinolaryngology, University Hospital of Antwerp (UZA), Antwerp, Belgium (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Medical Genetics: B M J Group44:9, s. 570-5780022-25931468-6244

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