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Contribution of the...
Contribution of the N-acetyltransferase 2 polymorphism NAT2*6A to age-related hearing impairment
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- Van Eyken, Els (author)
- Department of Medical Genetics, University of Antwerp (UA), Antwerp, Belgium
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- Van Camp, Guy (author)
- Department of Medical Genetics, University of Antwerp (UA), Antwerp, Belgium
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- Fransen, Erik (author)
- Department of Medical Genetics, University of Antwerp (UA), Antwerp, Belgium
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- Topsakal, Vedat (author)
- Department of Otorhinolaryngology, University Hospital of Antwerp (UZA), Antwerp, Belgium
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- Henricxk, Jan-Jaap (author)
- Department of Otorhinolaryngology, University Hospital of Antwerp (UZA), Antwerp, Belgium
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- Demeester, Kelly (author)
- Department of Otorhinolaryngology, University Hospital of Antwerp (UZA), Antwerp, Belgium
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- Van de Heyning, Paul (author)
- Department of Otorhinolaryngology, University Hospital of Antwerp (UZA), Antwerp, Belgium
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- Mäki-Torkko, Elina (author)
- Örebro universitet,Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Öronkliniken US,Department of Otorhinolaryngology, University of Oulu, Oulu, Finland,Institutionen för medicinska vetenskaper
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- Hannula, Samuli (author)
- Department of Otorhinolaryngology, University of Oulu, Oulu, Finland
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- Sorri, Martti (author)
- Department of Otorhinolaryngology, University of Oulu, Oulu, Finland
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- Jensen, Mona (author)
- Department of Audiology, Bispebjerg Hospital (BBH), Copenhagen, Denmark
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- Parving, Agnete (author)
- Department of Audiology, Bispebjerg Hospital (BBH), Copenhagen, Denmark
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- Bille, Mikael (author)
- Department of Audiology, Bispebjerg Hospital (BBH), Copenhagen, Denmark
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- Baur, Manuela (author)
- Department of Otorhinolaryngology, University of Tuebingen, Tuebingen, Germany
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- Pfister, Markus (author)
- Department of Otorhinolaryngology, University of Tuebingen, Tuebingen, Germany
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- Bonaconsa, Amanda (author)
- Department of Oto-surgery, University Hospital Padova, Padova, Italy
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- Mazzoli, Manuela (author)
- Department of Oto-surgery, University Hospital Padova, Padova, Italy,Department of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
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- Orzan, Eva (author)
- Department of Oto-surgery, University Hospital Padova, Padova, Italy
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- Espeso, Angeles (author)
- Welsh hearing Institute, University Hospital of Wales, Cardiff, UK
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- Stephens, Dafydd (author)
- Welsh hearing Institute, University Hospital of Wales, Cardiff, UK
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- Verbruggen, Katia (author)
- Department of Otorhinolaryngology, University Hospital of Gent (UZ), Gent, Belgium
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- Huyghe, Joke (author)
- Department of Otorhinolaryngology, University Hospital of Gent (UZ), Gent, Belgium
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- Dhooge, Ingeborg (author)
- Department of Otorhinolaryngology, University Hospital of Gent (UZ), Gent, Belgium
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- Huygen, Patrick (author)
- Radboud University Nijmegen Medical Centre, the Netherlands
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- Kremer, Hannie (author)
- Department of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
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- Cremers, Cor (author)
- Department of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
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- Kunst, Sylvia (author)
- Department of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
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- Manninen, Minna (author)
- Department of Otorhinolaryngology, University of Tampere, Tampere, Finland
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- Pyykkö, Ilmari (author)
- Department of Otorhinolaryngology, University of Tampere, Tampere, Finland
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- Lacava, A. (author)
- Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany
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- Steffens, Michael (author)
- Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany
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- Wienker, Thomas (author)
- Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany
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- Van Laer, Lut (author)
- Department of Medical Genetics, University of Antwerp (UA), Antwerp, Belgium
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(creator_code:org_t)
- 2007-05-11
- 2007
- English.
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In: Journal of Medical Genetics. - : B M J Group. - 0022-2593 .- 1468-6244. ; 44:9, s. 570-578
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- BackgroundAge‐related hearing impairment (ARHI) is the most common sensory impairment in older people, affecting 50% of those aged 80 years. The proportion of older people is increasing in the general population, and as a consequence, the number of people affected with ARHI is growing. ARHI is a complex disorder, with both environmental and genetic factors contributing to the disease. The first studies to elucidate these genetic factors were recently performed, resulting in the identification of the first two susceptibility genes for ARHI, NAT2 and KCNQ4.MethodsIn the present study, the association between ARHI and polymorphisms in genes that contribute to the defence against reactive oxygen species, including GSTT1, GSTM1 and NAT2, was tested. Samples originated from seven different countries and were combined into two test population samples, the general European population and the Finnish population. Two distinct phenotypes for ARHI were studied, Zlow and Zhigh, representing hearing in the low and high frequencies, respectively. Statistical analysis was performed for single polymorphisms (GSTM1, GSTT1, NAT2*5A, NAT2*6A, and NAT2*7A), haplotypes, and gene–environment and gene–gene interactions.ResultsWe found an association between ARHI and GSTT1 and GSTM1 in the Finnish population sample, and with NAT2*6A in the general European population sample. The latter finding replicates previously published data.ConclusionAs replication is considered the ultimate proof of true associations in the study of complex disorders, this study provides further support for the involvement of NAT2*6A in ARHI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Keyword
- N‐acetyltransferase
- age related hearing impairment
- association study
- complex disorder
- glutathione S‐transferase
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Van Eyken, Els
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Van Camp, Guy
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Fransen, Erik
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Topsakal, Vedat
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Henricxk, Jan-Ja ...
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Demeester, Kelly
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show more...
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Van de Heyning, ...
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Mäki-Torkko, Eli ...
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Hannula, Samuli
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Sorri, Martti
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Jensen, Mona
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Parving, Agnete
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Bille, Mikael
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Baur, Manuela
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Pfister, Markus
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Bonaconsa, Amand ...
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Mazzoli, Manuela
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Orzan, Eva
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Espeso, Angeles
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Stephens, Dafydd
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Verbruggen, Kati ...
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Huyghe, Joke
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Dhooge, Ingeborg
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Huygen, Patrick
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Kremer, Hannie
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Cremers, Cor
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Kunst, Sylvia
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Manninen, Minna
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Pyykkö, Ilmari
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Lacava, A.
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Steffens, Michae ...
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Wienker, Thomas
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Van Laer, Lut
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Otorhinolaryngol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Other Medical an ...
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and Gerontology spec ...
- Articles in the publication
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Journal of Medic ...
- By the university
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Linköping University
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Örebro University