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Selective arterial ...
Selective arterial chemoembolization for hepatic metastases from medullary thyroid carcinoma
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- Lorenz, Kerstin (author)
- Martin-Luther University of Halle-Wittenberg, Germany
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- Brauckhoff, Michael (author)
- Martin-Luther University of Halle-Wittenberg, Germany
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- Behrmann, Curd (author)
- Martin-Luther University of Halle-Wittenberg, Germany
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- Sekulla, Carsten (author)
- Martin-Luther University of Halle-Wittenberg, Germany
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- Ukkat, Jörg (author)
- Martin-Luther University of Halle-Wittenberg, Germany
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- Brauckhoff, Katrin (author)
- Martin-Luther University of Halle-Wittenberg, Germany
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- Gimm, Oliver (author)
- Martin-Luther University of Halle-Wittenberg, Germany
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- Dralle, Henning (author)
- Martin-Luther University of Halle-Wittenberg, Germany
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(creator_code:org_t)
- Elsevier, 2005
- 2005
- English.
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In: Surgery. - : Elsevier. - 0039-6060 .- 1532-7361. ; 138:6, s. 986-993
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: Hepatic metastases from medullary thyroid carcinoma (MTC) may impair quality of life by hypercalcitonemia-associated diarrhea and pain. In this prospective study, the effect of selective arterial chemoembolization (SACE) was evaluated.METHODS: Eleven patients with hepatic metastases from MTC received 1 to 9 courses of SACE using epirubicine. Symptomatic, biochemical, and morphologic responses on SACE were recorded.RESULTS: Symptomatic response was observed in all symptomatic patients. However, biochemical and radiologic response occurred only in 6 patients. Liver function was not affected by SACE. One patient with unexpected concurrent pheochromocytoma metastases died after the first course. Development of side effects in the course was observed in 8 patients but were only World Health Organization grade 1. Patients' satisfaction with SACE was excellent. Long-term follow-up found 7 patients alive (1-72 months). Three patients died with tumor 6, 12, and 24 months after SACE, respectively.CONCLUSION: SACE provided good symptom palliation for the majority of patients with hepatic metastases from MTC. However, transient remission or stabilization of hepatic metastases resulted in only 60%. Further studies using a randomized protocol are required.
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