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  • Hendrickx, Jan-JaapDepartment of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium; Department of Otorhinolaryngology, University of Oulu, Oulu, Finland; Department of Otorhinolaryngology, UMC Nijmegen, Nijmegen, Netherlands; Department of Otolaryngology, University Hospital Antwerp, Wilrijkstraat 10, Antwerp, Belgium (författare)

Familial aggregation of tinnitus : a European multicentre study

  • Artikel/kapitelEngelska2007

Förlag, utgivningsår, omfång ...

  • Louvain, Belgium :Societe Royale Belge d'Oto - Rhino - Laryngologie et de Chirurgie Cervico - Faciale,2007
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-101425
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-101425URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-63476URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:vet swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • INTRODUCTION AND AIM:Tinnitus is a common condition affecting approximately 20% of the older population. There is increasing evidence that changes in the central auditory system following cochlear malfunctioning are responsible for tinnitus. To date, few investigators have studied the influence of genetic factors on tinnitus. The present report investigates the presence of a familial effect in tinnitus subjects.METHODS:In a European multicentre study, 198 families were recruited in seven European countries. Each family had at least 3 siblings. Subjects were screened for causes of hearing loss other than presbyacusis by clinical examination and a questionnaire. The presence of tinnitus was evaluated with the question "Nowadays, do you ever get noises in your head or ear (tinnitus) which usually last longer than five minutes". Familial aggregation was tested using three methods: a mixed model approach, calculating familial correlations, and estimating the risk of a subject having tinnitus if the disorder is present in another family member.RESULTS:All methods demonstrated a significant familial effect for tinnitus. The effect persisted after correction for the effect of other risk factors such as hearing loss, gender and age. The size of the familial effect is smaller than that for age-related hearing impairment, with a familial correlation of 0.15.CONCLUSION:The presence of a familial effect for tinnitus opens the door to specific studies that can determine whether this effect is due to a shared familial environment or the involvement of genetic factors. Subsequent association studies may result in the identification of the factors responsible. In addition, more emphasis should be placed on the effect of role models in the treatment of tinnitus. 

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Huyghe, JeroenDepartment of Medical Genetics, University of Antwerp, Antwerp, Belgium (författare)
  • Demeester, KellyDepartment of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium (författare)
  • Topsakal, VelatDepartment of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium (författare)
  • Van Eyken, ElsDepartment of Medical Genetics, University of Antwerp, Antwerp, Belgium (författare)
  • Fransen, ErikDepartment of Medical Genetics, University of Antwerp, Antwerp, Belgium (författare)
  • Mäki-Torkko, ElinaÖrebro universitet,Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Öronkliniken US,Department of Otorhinolaryngology, University of Oulu, Oulu, Finland,Institutionen för medicinska vetenskaper(Swepub:oru)emo (författare)
  • Hannula, SamuliDepartment of Otorhinolaryngology, University of Oulu, Oulu, Finland (författare)
  • Jensen, MonaDepartment of Audiology, Bispebjerg Hospital, Copenhagen, Denmark (författare)
  • Tropitzsch, A.Department of Otorhinolaryngology, University of Tübingen, Tübingen, Germany (författare)
  • Bonaconsa, AmandaDepartment of Oto-surgery, University Hospital Padova, Padova, Italy (författare)
  • Mazzoli, ManuelaDepartment of Oto-surgery, University Hospital Padova, Padova, Italy,Department of Otorhinolaryngology, UMC Nijmegen, Nijmegen, Netherlands (författare)
  • Espesp, AngelesUniversity Hospital of Wales, Cardiff, UK,Welsh Hearing Institute, Cardiff University, Cardiff, United Kingdom (författare)
  • Verbruggen, KatiaDepartment of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium (författare)
  • Huyghe, JokeDepartment of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium (författare)
  • Huygen, PatrickRadboud University Nijmegen Medical Centre, the Netherlands (författare)
  • Kremer, HannieRadboud University Nijmegen Medical Centre, the Netherlands,Department of Otorhinolaryngology, UMC Nijmegen, Nijmegen, Netherlands (författare)
  • Kunst, SylviaRadboud University Nijmegen Medical Centre, the Netherlands,Department of Otorhinolaryngology, UMC Nijmegen, Nijmegen, Netherlands (författare)
  • Manninen, MinnaDepartment of Otorhinolaryngology, University of Tampere, Tampere, Finland (författare)
  • Diaz-Lacava, ANInstitute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany (författare)
  • Steffens, MichaelInstitute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany (författare)
  • Parving, AgneteDepartment of Audiology, Bispebjerg Hospital, Copenhagen, Denmark (författare)
  • Pyykkö, IlmariDepartment of Otorhinolaryngology, University of Tampere, Tampere, Finland (författare)
  • Dhooge, IngeborgDepartment of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium (författare)
  • Stephens, DafyddUniversity Hospital of Wales, Cardiff, UK,Welsh Hearing Institute, Cardiff University, Cardiff, United Kingdom (författare)
  • Orzan, EvaDepartment of Oto-surgery, University Hospital Padova, Padova, Italy (författare)
  • Pfister, MarkusDepartment of Otorhinolaryngology, University of Tübingen, Tübingen, Germany (författare)
  • Bille, MikaelDepartment of Audiology, Bispebjerg Hospital, Copenhagen, Denmark (författare)
  • Sorri, MarttiDepartment of Otorhinolaryngology, University of Oulu, Oulu, Finland (författare)
  • Cremers, CorRadboud University Nijmegen Medical Centre, the Netherlands,Department of Otorhinolaryngology, UMC Nijmegen, Nijmegen, Netherlands (författare)
  • Van Laer, LutDepartment of Medical Genetics, University of Antwerp, Antwerp, Belgium (författare)
  • Van Camp, GuyDepartment of Medical Genetics, University of Antwerp, Antwerp, Belgium (författare)
  • Wienker, ThomasInstitute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany (författare)
  • Van de Heyning, PaulDepartment of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium (författare)
  • Department of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium; Department of Otorhinolaryngology, University of Oulu, Oulu, Finland; Department of Otorhinolaryngology, UMC Nijmegen, Nijmegen, Netherlands; Department of Otolaryngology, University Hospital Antwerp, Wilrijkstraat 10, Antwerp, BelgiumDepartment of Medical Genetics, University of Antwerp, Antwerp, Belgium (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:B-ENTLouvain, Belgium : Societe Royale Belge d'Oto - Rhino - Laryngologie et de Chirurgie Cervico - Faciale3:Suppl 7, s. 51-600001-6497
  • Ingår i:B-ENTLouvain, Belgium : Societe Royale Belge d'Oto - Rhino - Laryngologie et de Chirurgie Cervico - Faciale3:Suppl 7, s. 51-601781-782X

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