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Dissecting molecula...
Dissecting molecular events in thyroid neoplasia provides evidence for distinct evolution of follicular thyroid adenoma and carcinoma.
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- Krause, Kerstin (författare)
- Clinic for Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany
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- Prawitt, Susanne (författare)
- Clinic for Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany
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- Eszlinger, Markus (författare)
- Clinic for Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany
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- Ihling, Christian (författare)
- Department of Pharmaceutical Chemistry and Bioanalytics, Martin Luther University of Halle- Wittenberg, Halle-Wittenberg, Germany
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- Sinz, Andrea (författare)
- Department of Pharmaceutical Chemistry and Bioanalytics, Martin Luther University of Halle- Wittenberg, Halle-Wittenberg, Germany
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- Schierle, Katrin (författare)
- Institute of Pathology, University of Leipzig, Leipzig
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- Gimm, Oliver (författare)
- Department of General, Visceral, and Vascular Surgery, Martin Luther University of Halle- Wittenberg, Halle-Wittenberg, Germany
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- Dralle, Henning (författare)
- Department of General, Visceral, and Vascular Surgery, Martin Luther University of Halle- Wittenberg, Halle-Wittenberg, Germany
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- Steinert, Frank (författare)
- Centre for Minimally Invasive and Laparoscopic Surgery, Helios Clinic Schkeuditz, Schkeuditz, University of Duisburg-Essen, Essen, Germany
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- Sheu, Sien-Yi (författare)
- nstitute of Pathology and Neuropathology, University of Duisburg-Essen, Essen, Germany
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- Schmid, Kurt W (författare)
- nstitute of Pathology and Neuropathology, University of Duisburg-Essen, Essen, Germany
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- Fuhrer, Dagmar (författare)
- Clinic for Endocrinology, University of Duisburg-Essen, Essen, Germany
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- Engelska.
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Ingår i: American Journal of Pathology. - : Elsevier BV. - 0002-9440 .- 1525-2191. ; 179:6, s. 3066-74
- Relaterad länk:
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http://ajp.amjpathol...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Benign hypofunctional cold thyroid nodules (CTNs) are a frequent scintiscan finding and need to be distinguished from thyroid carcinomas. The origin of CTNs with follicular morphologic features is unresolved. The DNA damage response might act as a physiologic barrier, inhibiting the progression of preneoplastic lesions to neoplasia. We investigated the following in hypofunctional follicular adenoma (FA) and follicular thyroid cancer (FTC): i) the mutation rate of frequently activated oncogenes, ii) the activation of DNA damage response checkpoints, and iii) the differential proteomic pattern between FA and FTC. Both FTC and FA, which did not harbor RAS, phosphoinositide-3-kinase, or PAX/peroxisome proliferator activated receptor-γ mutations, express various proteins in common and others that are more distinctly expressed in FTC rather than in FA or normal thyroid tissue. This finding is in line with the finding of constitutive DNA damage checkpoint activation (p-Chk2, γ-H2AX) and evidence for replicative stress causing genomic instability (increased cyclin E, retinoblastoma, or E2F1 mRNA expression) in FTC but not FA. We discuss the findings of the increased expression of translationally controlled tumor protein, phosphatase 2A inhibitor, and DJ-1 in FTC compared with FA identified by proteomics and their potential implication in follicular thyroid carcinogenesis. Our present findings argue for the definition of FA as a truly benign entity and against progressive development of FA to FTC.
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Krause, Kerstin
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Prawitt, Susanne
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Eszlinger, Marku ...
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Ihling, Christia ...
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Sinz, Andrea
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Schierle, Katrin
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visa fler...
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Gimm, Oliver
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Dralle, Henning
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Steinert, Frank
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Sheu, Sien-Yi
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Schmid, Kurt W
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Fuhrer, Dagmar
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