Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren's syndrome

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Lessard, Christopher J.Oklahoma Medical Research Fdn, OK USA (author)

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren's syndrome

Article/chapterEnglish2013

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2013-10-06
NATURE PUBLISHING GROUP, 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA,2013
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LIBRIS-ID:oai:DiVA.org:liu-102078
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-102078URI
https://doi.org/10.1038/ng.2792DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-210966URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:127684101URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Funding Agencies|NIH|P50 AR06080405P01 AR049084-105P30 AR0534831U01 AI1019345P30 GM103510|Intramural Research Program of the National Institute of Dental and Craniofacial Research||American College of Rheumatology Research and Education Foundation/Abbott Health Professional Graduate Student Preceptorship Award||
Sjogrens syndrome is a common autoimmune disease (affecting similar to 0.7% of European Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report results of a large-scale association study of Sjogrens syndrome. In addition to strong association within the human leukocyte antigen (HLA) region at 6p21 (P-meta = 7.65 x 10(-114)), we establish associations with IRF5-TNPO3 (P-meta = 2.73 x 10(-19)), STAT4 (Pmeta = 6.80 x 10-15), IL12A (P-meta = 1.17 x 10(-10)), FAM167ABLK (P-meta = 4.97 x 10(-10)), DDX6-CXCR5 (P-meta = 1.10 x 10(-8)) and TNIP1 (P-meta = 3.30 x 10(-8)). We also observed suggestive associations (P-meta andlt; 5 x 10(-5)) with variants in 29 other regions, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others. These results highlight the importance of genes that are involved in both innate and adaptive immunity in Sjogrens syndrome.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reumatologi och inflammation hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Rheumatology and Autoimmunity hsv//eng
TECHNOLOGY
TEKNIKVETENSKAP
Medicin

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Li, HeOklahoma Medical Research Fdn, OK USA (author)
Adrianto, IndraOklahoma Medical Research Fdn, OK USA (author)
Ice, John A.Oklahoma Medical Research Fdn, OK USA (author)
Rasmussen, AstridOklahoma Medical Research Fdn, OK USA (author)
Grundahl, Kiely M.Oklahoma Medical Research Fdn, OK USA (author)
Kelly, Jennifer A.Oklahoma Medical Research Fdn, OK USA (author)
Dozmorov, Mikhail G.Oklahoma Medical Research Fdn, OK USA (author)
Miceli-Richard, CorinneUniversity of Paris 11, France (author)
Bowman, SimonUniversity Hospital Birmingham, England (author)
Lester, SueQueen Elizabeth Hospital, Australia (author)
Eriksson, PerÖstergötlands Läns Landsting,Linköpings universitet,Reumatologi,Hälsouniversitetet,Reumatologiska kliniken i Östergötland(Swepub:liu)perer22 (author)
Eloranta, Maija-LeenaUppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Sweden(Swepub:uu)maelo020 (author)
Brun, Johan G.University of Bergen, Norway (author)
Goransson, Lasse G.Stavanger University Hospital, Norway (author)
Harboe, ErnaStavanger University Hospital, Norway (author)
Guthridge, Joel M.Oklahoma Medical Research Fdn, OK USA (author)
Kaufman, Kenneth M.Cincinnati Childrens Hospital Medical Centre, OH USA (author)
Kvarnstrom, MarikaKarolinska Institutet,Karolinska Institute, Sweden (author)
Jazebi, HelmiKarolinska Institute, Sweden (author)
Cunninghame Graham, Deborah S.Kings Coll London, England (author)
Grandits, Martha E.United Medical Specialties, MN USA (author)
Nazmul-Hossain, Abu N M.University of Colorado, CO USA (author)
Patel, KetanUniversity of Minnesota, MN USA (author)
Adler, Adam J.Oklahoma Medical Research Fdn, OK USA,Valley Bone and Joint Clin, ND USA (author)
Maier-Moore, Jacen S.Oklahoma Medical Research Fdn, OK USA (author)
Darise Farris, AOklahoma Medical Research Fdn, OK USA (author)
Brennan, Michael T.Carolinas Medical Centre, NC USA (author)
Lessard, James A.Valley Bone and Joint Clin, ND USA (author)
Chodosh, JamesHarvard University, MA USA (author)
Gopalakrishnan, RajaramUniversity of Minnesota, MN USA (author)
Hefner, Kimberly S.Hefner Eye Care and Opt Centre, OK USA (author)
Houston, Glen D.University of Oklahoma, OK USA (author)
Huang, Andrew J W.Washington University, MO USA (author)
Hughes, Pamela J.University of Oklahoma, OK USA (author)
Lewis, David M.University of Oklahoma, OK USA (author)
Radfar, LidaUniversity of Oklahoma, OK USA (author)
Rohrer, Michael D.University of Minnesota, MN USA (author)
Stone, Donald U.University of Oklahoma, OK USA (author)
Wren, Jonathan D.Oklahoma Medical Research Fdn, OK USA (author)
Vyse, Timothy J.Kings Coll London, England (author)
Gaffney, Patrick M.Oklahoma Medical Research Fdn, OK USA (author)
James, Judith A.Oklahoma Medical Research Fdn, OK USA (author)
Omdal, RoaldStavanger University Hospital, Norway (author)
Wahren-Herlenius, MarieKarolinska Institutet,Karolinska Institute, Sweden (author)
Illei, Gabor G.National Institute Dent and Craniofacial Research, MD USA (author)
Witte, TorstenHannover Medical Sch, Germany (author)
Jonsson, RolandHaukeland Hospital, Norway (author)
Rischmueller, MaureenQueen Elizabeth Hospital, Australia (author)
Rönnblom, LarsUppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Sweden(Swepub:uu)larsronn (author)
Nordmark, GunnelUppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Sweden(Swepub:uu)gunnnord (author)
Ng, Wan-FaiNewcastle University, England (author)
Mariette, XavierUniversity of Paris 11, France (author)
Anaya, Juan-ManuelUniversity of Rosario, Colombia (author)
Rhodus, Nelson L.University of Minnesota, MN USA (author)
Segal, Barbara M.University of Minnesota, MN USA (author)
Hal Scofield, ROklahoma Medical Research Fdn, OK USA (author)
Montgomery, Courtney G.Oklahoma Medical Research Fdn, OK USA (author)
Harley, John B.Cincinnati Childrens Hospital Medical Centre, OH USA (author)
Sivils, Kathy L.Oklahoma Medical Research Fdn, OK USA (author)
Oklahoma Medical Research Fdn, OK USAUniversity of Paris 11, France (creator_code:org_t)

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In:Nature Genetics: NATURE PUBLISHING GROUP, 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA45:11, s. 1284-+1061-40361546-1718

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By the author/editor: Lessard, Christo ...; Li, He; Adrianto, Indra; Ice, John A.; Rasmussen, Astri ...; Grundahl, Kiely ...; show more...; Kelly, Jennifer ...; Dozmorov, Mikhai ...; Miceli-Richard, ...; Bowman, Simon; Lester, Sue; Eriksson, Per; Eloranta, Maija- ...; Brun, Johan G.; Goransson, Lasse ...; Harboe, Erna; Guthridge, Joel ...; Kaufman, Kenneth ...; Kvarnstrom, Mari ...; Jazebi, Helmi; Cunninghame Grah ...; Grandits, Martha ...; Nazmul-Hossain, ...; Patel, Ketan; Adler, Adam J.; Maier-Moore, Jac ...; Darise Farris, A; Brennan, Michael ...; Lessard, James A ...; Chodosh, James; Gopalakrishnan, ...; Hefner, Kimberly ...; Houston, Glen D.; Huang, Andrew J ...; Hughes, Pamela J ...; Lewis, David M.; Radfar, Lida; Rohrer, Michael ...; Stone, Donald U.; Wren, Jonathan D ...; Vyse, Timothy J.; Gaffney, Patrick ...; James, Judith A.; Omdal, Roald; Wahren-Herlenius ...; Illei, Gabor G.; Witte, Torsten; Jonsson, Roland; Rischmueller, Ma ...; Rönnblom, Lars; Nordmark, Gunnel; Ng, Wan-Fai; Mariette, Xavier; Anaya, Juan-Manu ...; Rhodus, Nelson L ...; Segal, Barbara M ...; Hal Scofield, R; Montgomery, Cour ...; Harley, John B.; Sivils, Kathy L.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Rheumatology and ...

Articles in the publication: Nature Genetics

By the university: Linköping University; Uppsala University; Karolinska Institutet

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