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Variants at multipl...
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Lessard, Christopher J.Oklahoma Medical Research Fdn, OK USA
(author)
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren's syndrome
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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2013-10-06
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NATURE PUBLISHING GROUP, 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA,2013
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-102078
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-102078URI
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https://doi.org/10.1038/ng.2792DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-210966URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:127684101URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|NIH|P50 AR06080405P01 AR049084-105P30 AR0534831U01 AI1019345P30 GM103510|Intramural Research Program of the National Institute of Dental and Craniofacial Research||American College of Rheumatology Research and Education Foundation/Abbott Health Professional Graduate Student Preceptorship Award||
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Sjogrens syndrome is a common autoimmune disease (affecting similar to 0.7% of European Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report results of a large-scale association study of Sjogrens syndrome. In addition to strong association within the human leukocyte antigen (HLA) region at 6p21 (P-meta = 7.65 x 10(-114)), we establish associations with IRF5-TNPO3 (P-meta = 2.73 x 10(-19)), STAT4 (Pmeta = 6.80 x 10-15), IL12A (P-meta = 1.17 x 10(-10)), FAM167ABLK (P-meta = 4.97 x 10(-10)), DDX6-CXCR5 (P-meta = 1.10 x 10(-8)) and TNIP1 (P-meta = 3.30 x 10(-8)). We also observed suggestive associations (P-meta andlt; 5 x 10(-5)) with variants in 29 other regions, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others. These results highlight the importance of genes that are involved in both innate and adaptive immunity in Sjogrens syndrome.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Li, HeOklahoma Medical Research Fdn, OK USA
(author)
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Adrianto, IndraOklahoma Medical Research Fdn, OK USA
(author)
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Ice, John A.Oklahoma Medical Research Fdn, OK USA
(author)
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Rasmussen, AstridOklahoma Medical Research Fdn, OK USA
(author)
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Grundahl, Kiely M.Oklahoma Medical Research Fdn, OK USA
(author)
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Kelly, Jennifer A.Oklahoma Medical Research Fdn, OK USA
(author)
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Dozmorov, Mikhail G.Oklahoma Medical Research Fdn, OK USA
(author)
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Miceli-Richard, CorinneUniversity of Paris 11, France
(author)
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Bowman, SimonUniversity Hospital Birmingham, England
(author)
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Lester, SueQueen Elizabeth Hospital, Australia
(author)
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Eriksson, PerÖstergötlands Läns Landsting,Linköpings universitet,Reumatologi,Hälsouniversitetet,Reumatologiska kliniken i Östergötland(Swepub:liu)perer22
(author)
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Eloranta, Maija-LeenaUppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Sweden(Swepub:uu)maelo020
(author)
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Brun, Johan G.University of Bergen, Norway
(author)
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Goransson, Lasse G.Stavanger University Hospital, Norway
(author)
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Harboe, ErnaStavanger University Hospital, Norway
(author)
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Guthridge, Joel M.Oklahoma Medical Research Fdn, OK USA
(author)
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Kaufman, Kenneth M.Cincinnati Childrens Hospital Medical Centre, OH USA
(author)
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Kvarnstrom, MarikaKarolinska Institutet,Karolinska Institute, Sweden
(author)
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Jazebi, HelmiKarolinska Institute, Sweden
(author)
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Cunninghame Graham, Deborah S.Kings Coll London, England
(author)
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Grandits, Martha E.United Medical Specialties, MN USA
(author)
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Nazmul-Hossain, Abu N M.University of Colorado, CO USA
(author)
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Patel, KetanUniversity of Minnesota, MN USA
(author)
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Adler, Adam J.Oklahoma Medical Research Fdn, OK USA,Valley Bone and Joint Clin, ND USA
(author)
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Maier-Moore, Jacen S.Oklahoma Medical Research Fdn, OK USA
(author)
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Darise Farris, AOklahoma Medical Research Fdn, OK USA
(author)
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Brennan, Michael T.Carolinas Medical Centre, NC USA
(author)
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Lessard, James A.Valley Bone and Joint Clin, ND USA
(author)
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Chodosh, JamesHarvard University, MA USA
(author)
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Gopalakrishnan, RajaramUniversity of Minnesota, MN USA
(author)
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Hefner, Kimberly S.Hefner Eye Care and Opt Centre, OK USA
(author)
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Houston, Glen D.University of Oklahoma, OK USA
(author)
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Huang, Andrew J W.Washington University, MO USA
(author)
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Hughes, Pamela J.University of Oklahoma, OK USA
(author)
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Lewis, David M.University of Oklahoma, OK USA
(author)
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Radfar, LidaUniversity of Oklahoma, OK USA
(author)
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Rohrer, Michael D.University of Minnesota, MN USA
(author)
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Stone, Donald U.University of Oklahoma, OK USA
(author)
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Wren, Jonathan D.Oklahoma Medical Research Fdn, OK USA
(author)
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Vyse, Timothy J.Kings Coll London, England
(author)
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Gaffney, Patrick M.Oklahoma Medical Research Fdn, OK USA
(author)
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James, Judith A.Oklahoma Medical Research Fdn, OK USA
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Omdal, RoaldStavanger University Hospital, Norway
(author)
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Wahren-Herlenius, MarieKarolinska Institutet,Karolinska Institute, Sweden
(author)
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Illei, Gabor G.National Institute Dent and Craniofacial Research, MD USA
(author)
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Witte, TorstenHannover Medical Sch, Germany
(author)
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Jonsson, RolandHaukeland Hospital, Norway
(author)
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Rischmueller, MaureenQueen Elizabeth Hospital, Australia
(author)
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Rönnblom, LarsUppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Sweden(Swepub:uu)larsronn
(author)
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Nordmark, GunnelUppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Sweden(Swepub:uu)gunnnord
(author)
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Ng, Wan-FaiNewcastle University, England
(author)
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Mariette, XavierUniversity of Paris 11, France
(author)
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Anaya, Juan-ManuelUniversity of Rosario, Colombia
(author)
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Rhodus, Nelson L.University of Minnesota, MN USA
(author)
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Segal, Barbara M.University of Minnesota, MN USA
(author)
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Hal Scofield, ROklahoma Medical Research Fdn, OK USA
(author)
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Montgomery, Courtney G.Oklahoma Medical Research Fdn, OK USA
(author)
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Harley, John B.Cincinnati Childrens Hospital Medical Centre, OH USA
(author)
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Sivils, Kathy L.Oklahoma Medical Research Fdn, OK USA
(author)
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Oklahoma Medical Research Fdn, OK USAUniversity of Paris 11, France
(creator_code:org_t)
Related titles
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In:Nature Genetics: NATURE PUBLISHING GROUP, 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA45:11, s. 1284-+1061-40361546-1718
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Lessard, Christo ...
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Li, He
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Adrianto, Indra
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Ice, John A.
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Rasmussen, Astri ...
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Grundahl, Kiely ...
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Kelly, Jennifer ...
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Dozmorov, Mikhai ...
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Miceli-Richard, ...
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Bowman, Simon
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Lester, Sue
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Eriksson, Per
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Eloranta, Maija- ...
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Brun, Johan G.
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Goransson, Lasse ...
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Harboe, Erna
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Guthridge, Joel ...
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Kaufman, Kenneth ...
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Kvarnstrom, Mari ...
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Jazebi, Helmi
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Cunninghame Grah ...
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Grandits, Martha ...
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Nazmul-Hossain, ...
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Patel, Ketan
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Adler, Adam J.
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Maier-Moore, Jac ...
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Darise Farris, A
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Brennan, Michael ...
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Lessard, James A ...
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Chodosh, James
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Gopalakrishnan, ...
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Hefner, Kimberly ...
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Houston, Glen D.
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Huang, Andrew J ...
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Hughes, Pamela J ...
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Lewis, David M.
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Radfar, Lida
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Rohrer, Michael ...
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Stone, Donald U.
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Wren, Jonathan D ...
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Vyse, Timothy J.
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Gaffney, Patrick ...
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James, Judith A.
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Omdal, Roald
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Wahren-Herlenius ...
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Illei, Gabor G.
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Witte, Torsten
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Jonsson, Roland
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Rischmueller, Ma ...
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Rönnblom, Lars
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Nordmark, Gunnel
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Ng, Wan-Fai
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Mariette, Xavier
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Anaya, Juan-Manu ...
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Rhodus, Nelson L ...
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Segal, Barbara M ...
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Hal Scofield, R
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Montgomery, Cour ...
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Harley, John B.
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Sivils, Kathy L.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Nature Genetics
- By the university
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Linköping University
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Uppsala University
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Karolinska Institutet