Persistent organic pollutants and abnormal geometry of the left ventricle in the elderly

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Lind Monica) > Persistent organic ...

Details
MARC

Sjöberg Lind, YlvaDepartment of Emergency Medicine, Linköping University Hospital,Dept Emergency Med, Linköping University Hospital, Linköping, Sweden (author)

Persistent organic pollutants and abnormal geometry of the left ventricle in the elderly

Article/chapterEnglish2013

Publisher, publication year, extent ...

Lippincott Williams & Wilkins,2013
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:liu-102411
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-102411URI
https://doi.org/10.1097/HJH.0b013e32836221b3DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-54794URI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-212428URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Funding Agencies|Swedish Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS)||Swedish Research Council (VR)||
Background:Established risk factors for left ventricular hypertrophy (LVH) are hypertension, diabetes, and obesity. However, as these risk factors explain only part of the variation in left ventricular mass, we investigated whether persistent organic pollutants (POPs) might also play a role in LVH, because exposure to polychlorinated biphenyl 126 induced cardiac growth in rats.Methods:In the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS), left ventricular mass index (LVMI), relative wall thickness (RWT), and geometric groups of LVH, were determined by echocardiography and 21 POPs were measured by high-resolution chromatography coupled to high-resolution mass spectrometry (HRGC/HRMS) in 1016 individuals aged 70 years. All individuals with a history of myocardial infarction were excluded from analysis (n=72).Results:Several of the POPs were related to abnormal left ventricular geometry before adjustment for established risk factors, but lost in significance following adjustment. However, the pesticide hexachlorobenzene (HCB) levels were significantly related to RWT, and concentric left ventricular remodeling, also following adjustment for sex, blood pressure, antihypertensive treatment, diabetes, and BMI (Pandlt;0.0001).Conclusion:In this cross-sectional study, circulating levels of HCB were related to increased wall thickness of the left ventricle and concentric left ventricular remodeling, independently of LVH risk factors, suggesting a role of this environmental contaminant in abnormal growth of the left ventricle.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
echocardiography
elderly
hexachlorobenzene
left ventricular hypertrophy
persistent organic pollutants
pesticides
polychlorinated biphenyls

Added entries (persons, corporate bodies, meetings, titles ...)

Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi,Uppsala University, Sweden(Swepub:uu)larslind (author)
Salihovic, Samira,1985-Örebro universitet,Institutionen för naturvetenskap och teknik,Örebro University, Sweden(Swepub:oru)sasc (author)
van Bavel, Bert,1963-Örebro universitet,Institutionen för naturvetenskap och teknik,Örebro University, Sweden(Swepub:oru)bvl (author)
Lind, P. MonicaUppsala universitet,Arbets- och miljömedicin,Uppsala University, Sweden(Swepub:uu)monilind (author)
Department of Emergency Medicine, Linköping University HospitalDept Emergency Med, Linköping University Hospital, Linköping, Sweden (creator_code:org_t)

Related titles

In:Journal of Hypertension: Lippincott Williams & Wilkins31:8, s. 1547-15530263-63521473-5598

Internet link

Find in a library

Journal of Hypertension (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Sjöberg Lind, Yl ...; Lind, Lars; Salihovic, Samir ...; van Bavel, Bert, ...; Lind, P. Monica

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

Articles in the publication: Journal of Hyper ...

By the university: Linköping University; Örebro University; Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se