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Allogeneic stem cel...
Allogeneic stem cell transplantation for patients with advanced rhabdomyosarcoma: a retrospective assessment
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- Thiel, U (author)
- Technical University of Munich, Germany
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- Koscielniak, E (author)
- Klinikum Stuttgart, Germany
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- Blaeschke, F (author)
- Technical University of Munich, Germany
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- Grunewald, T G P. (author)
- Technical University of Munich, Germany
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- Badoglio, M (author)
- Hop St Antoine, France
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- Diaz, M A. (author)
- Hospital Infantil University of Nino Jesus, Spain
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- Paillard, C (author)
- CHU Clermont Ferrand, France
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- Prete, A (author)
- Osped S Orsola Malpighi, Italy
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- Ussowicz, M (author)
- Wroclaw Medical University, Poland
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- Lang, P (author)
- University of Childrens Hospital, Germany
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- Fagioli, F (author)
- Regina Margherita Childrens Hospital, Italy
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- Lutz, P (author)
- Hop Hautepierre, France
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- Ehninger, G (author)
- University Hospital Carl Gustav Carus, Germany
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- Schneider, P (author)
- Rouen University Hospital, France
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- Santucci, A (author)
- University of Perugia, Italy
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- Bader, P (author)
- Goethe University of Frankfurt, Germany
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- Gruhn, B (author)
- Jena University Hospital, Germany
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- Faraci, M (author)
- G Gaslini Childrens Research Institute, Italy
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- Antunovic, Petar (author)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
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- Styczynski, J (author)
- Coll Medical UMK, Poland
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- Krueger, W H. (author)
- Ernst Moritz Arndt University of Greifswald, Germany
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- Castagna, L (author)
- Ist Clin Humanitas, Italy
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- Rohrlich, P (author)
- University of Franche Comte, France
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- Ouachee-Chardin, M (author)
- Hop Robert Debre, France
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- Salmon, A (author)
- CHU Nancy Brabois, France
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- Peters, C (author)
- St Anna Childrens Hospital, Austria
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- Bregni, M (author)
- Osped Circolo, Italy
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- Burdach, S (author)
- Technical University of Munich, Germany
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(creator_code:org_t)
- 2013-10-22
- 2013
- English.
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In: British Journal of Cancer. - : Cancer Research UK. - 0007-0920 .- 1532-1827. ; 109:10, s. 2523-2532
- Related links:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Allogeneic haematopoietic stem cell transplantation (allo-SCT) may provide donor cytotoxic T cell-/NK cell-mediated disease control in patients with rhabdomyosarcoma (RMS). However, little is known about the prevalence of graft-vs-RMS effects and only a few case experiences have been reported. less thanbrgreater than less thanbrgreater thanMethods: We evaluated allo-SCT outcomes of 30 European Group for Blood and Marrow Transplantation (EBMT)-registered patients with advanced RMS regarding toxicity, progression-free survival (PFS) and overall survival (OS) after allo-SCT. Twenty patients were conditioned with reduced intensity and ten with high-dose chemotherapy. Twenty-three patients were transplanted with HLA-matched and seven with HLA-mismatched grafts. Three patients additionally received donor lymphocyte infusions (DLIs). Median follow-up was 9 months. less thanbrgreater than less thanbrgreater thanResults: Three-year OS was 20% (s. e.+/- 8%) with a median survival time of 12 months. Cumulative risk of progression was 67% (s. e.+/- 10%) and 11% (s. e.+/- 6%) for death of complications. Thirteen patients developed acute graft-vs-host disease (GvHD) and five developed chronic GvHD. Eighteen patients died of disease and four of complications. Eight patients survived in complete remission (CR) (median: 44 months). No patients with residual disease before allo-SCT were converted to CR. less thanbrgreater than less thanbrgreater thanConclusion: The use of allo-SCT in patients with advanced RMS is currently experimental. In a subset of patients, it may constitute a valuable approach for consolidating CR, but this needs to be validated in prospective trials.
Keyword
- rhabdomyosarcoma
- allogeneic haematopoietic stem cell transplantation
- graft-vs-tumour effect
- reduced intensity conditioning
- myeloablative conditioning
- donor lymphocyte infusion
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Thiel, U
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Koscielniak, E
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Blaeschke, F
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Grunewald, T G P ...
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Badoglio, M
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Diaz, M A.
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show more...
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Paillard, C
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Prete, A
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Ussowicz, M
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Lang, P
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Fagioli, F
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Lutz, P
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Ehninger, G
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Schneider, P
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Santucci, A
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Bader, P
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Gruhn, B
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Faraci, M
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Antunovic, Petar
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Styczynski, J
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Krueger, W H.
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Castagna, L
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Rohrlich, P
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Ouachee-Chardin, ...
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Salmon, A
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Peters, C
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Bregni, M
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Burdach, S
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- Articles in the publication
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British Journal ...
- By the university
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Linköping University