Genetic relatedness of multi-resistant methicillin-susceptible Staphylococcus aureus in southeast Sweden

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MARC

Lindqvist, MariaÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet,Vårdhygien (author)

Genetic relatedness of multi-resistant methicillin-susceptible Staphylococcus aureus in southeast Sweden

BookEnglish2014

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2014
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:liu-103678
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-103678URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:vet swepub-contenttype
Subject category:ovr swepub-publicationtype

Notes

Background: A high exchange of patients occurs between the hospitals in southeast Sweden, resulting in a possible transmission of nosocomial pathogens. The objective of this study was to investigate the incidence and possible genetic relatedness of multi-resistant methicillinsusceptible Staphylococcus aureus (MSSA) in the region in general, and in particular the possible persistence and transmission of the ECT-R clone (t002) showing resistance to erythromycin, clindamycin and tobramycin previously found in Östergötland County.Methods: Three groups of S. aureus isolates with different antibiotic resistance profiles, including the ECT-R profile, were collected from the three County Councils in southeast Sweden and investigated with spa typing, real-time PCR targeting the staphylococcal cassette chromosome (SCC) mec right extremity junction (MREJ), and microarray.Results: All isolates with the ECT-R resistance profile (n = 12) from Östergötland County and two additional isolates with another antibiotic resistance profile were designated spa type t002, MREJ type ii, and were clustered in the same clonal cluster (CC) (i.e. CC5) by the microarray result, indicating the persistence of the ECT-R clone. In addition, 60 % of the isolates belonged to CC15 from newborns, with 94 % sharing spa type t084, indicating interhospital transmission.Conclusions: The persistence of the ECT-R clone and the possible transmission of the t084 strain indicate that there is still an insufficiency in the maintenance of basic hygiene guidelines. The ECT-R clone probably possesses mechanisms of virulence and transmission that make it so successful.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
MSSA
multi-resistance
genetic relatedness
t002
t084
MEDICINE
MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

Isaksson, BarbroÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet,Vårdhygien,Klinisk mikrobiologi(Swepub:liu)baris12 (author)
Nilsson, LennartLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet(Swepub:liu)lenni43 (author)
Wistedt, AnnikaDepartment of Clinical Microbiology and Infection Control, Kalmar County Hospital, Kalmar, Sweden (author)
Swanberg, JonasClinical Microbiology Laboratory, Ryhov Hospital, Jönköping, Sweden (author)
Skov, RobertStaphylococcus Laboratory, Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark (author)
Rhod Larsen, AndersStaphylococcus Laboratory, Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark (author)
Larsen, JesperStaphylococcus Laboratory, Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark (author)
Petersen, AndreasStaphylococcus Laboratory, Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark (author)
Hällgren, AnitaÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet,Infektionskliniken i Östergötland(Swepub:liu)aniha32 (author)
Linköpings universitetAvdelningen för mikrobiologi och molekylär medicin (creator_code:org_t)

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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-103678

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By the author/editor: Lindqvist, Maria; Isaksson, Barbro; Nilsson, Lennart; Wistedt, Annika; Swanberg, Jonas; Skov, Robert; show more...; Rhod Larsen, And ...; Larsen, Jesper; Petersen, Andrea ...; Hällgren, Anita; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

By the university: Linköping University

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