WFRF:(Vaarala Outi)
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- Lahdenperä, AnneLinköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet (författare)
Expression pattern of T-helper 17 cell signaling pathway and mucosal inflammation in celiac disease
- Artikel/kapitelEngelska2014
Förlag, utgivningsår, omfång ...
- 2013-12-10
- Informa Healthcare,2014
- electronicrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:liu-104288
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-104288URI
- https://doi.org/10.3109/00365521.2013.863966DOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
Klassifikation
Anmärkningar
- Objective. The aim was to investigate the mucosal activation of a broad range of genes associated with the T-helper 17 cell (Th17) signaling pathway in children at different stages of celiac disease (CD), including children with increased risk for CD and children with untreated and gluten-free diet (GFD)-treated CD. Material and methods. Small intestinal biopsies were taken from children with untreated and GFD-treated CD, transglutaminase antibody (TGA)-positive children with potential CD, and reference children. Real-time polymerase chain reaction (PCR) arrays were used to study the gene expression pattern of Th17-related genes, and quantitative PCR was used to study the interleukin (IL)-17A expression. Results. The mucosal expression of CD8A was elevated at all stages of CD. Children with untreated CD had diminished levels of IL-17RE, IL-23R, RORc, STAT6, CCL22, NFATC2, IL-18, CD4, CD247, and matrix metalloproteinase (MMP)9 but had elevated levels of MMP3, IL-17, interferon-gamma (IFN-gamma) and CD8A, compared to references. The majority of the aforementioned genes, being differentially expressed in untreated CD, displayed similar expression in GFD-treated children and references. Children with untreated and GFD-treated CD had elevated expression of IFN-gamma but had reduced expression of CD247. Interestingly, children with potential CD displayed reduced FOXP3, IL-21, and IL-17A levels. Conclusion. Mucosal upregulation of Th17 immunity occurs at the late stage of disease and is downregulated with dietary treatment, thus indicating that IL-17 immunity is not a fundamental feature of CD as Th1 immunity, which is not fully downregulated by GFD.
Ämnesord och genrebeteckningar
- arrays; celiac disease; children; gene expression; gluten-free diet; IL-17; mucosa; Th17
- MEDICINE
- MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Fälth-Magnusson, KarinÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping(Swepub:liu)karfa12 (författare)
- Hogberg, LottaNorrkoping Hospital, Sweden (författare)
- Ludvigsson, JohnnyÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping(Swepub:liu)johlu29 (författare)
- Vaarala, OutiNational Institute Health and Welf, Finland (författare)
- Linköpings universitetAvdelningen för kliniska vetenskaper (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Scandinavian Journal of Gastroenterology: Informa Healthcare49:2, s. 145-1560036-55211502-7708
Internetlänk
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- Scandinavian Journal of Gastroenterology (Sök värdpublikationen i LIBRIS)
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- Lahdenperä, Anne
- Fälth-Magnusson, ...
- Hogberg, Lotta
- Ludvigsson, John ...
- Vaarala, Outi
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- Linköpings universitet
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