Search: WFRF:(Pozzilli C) >
Age-dependent decli...
Age-dependent decline of beta-cell function in type 1 diabetes after diagnosis: a multi-centre longitudinal study
-
- Barker, A. (author)
- Cambridge Institute Public Heatlh, England
-
- Lauria, A. (author)
- University of Campus Biomed, Italy
-
- Schloot, N. (author)
- University of Dusseldorf, Germany University of Dusseldorf, Germany
-
show more...
-
- Hosszufalusi, N. (author)
- Semmelweis University, Hungary
-
- Ludvigsson, Johnny (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping
-
- Mathieu, C. (author)
- Katholieke University of Leuven, Belgium
-
- Mauricio, D. (author)
- Hospital Arnau Vilanova, Spain
-
- Nordwall, Maria (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Barn- och ungdomskliniken i Norrköping
-
- Van der Schueren, B. (author)
- Katholieke University of Leuven, Belgium
-
- Mandrup-Poulsen, T. (author)
- University of Copenhagen, Denmark
-
- Scherbaum, W .A. (author)
- University of Dusseldorf, Germany
-
- Weets, I. (author)
- Vrije University of Brussel, Belgium Vrije University of Brussel, Belgium Belgian Diabet Registry BDR, Belgium
-
- Gorus, F. K. (author)
- Vrije University of Brussel, Belgium Vrije University of Brussel, Belgium Belgian Diabet Registry BDR, Belgium
-
- Wareham, N. (author)
- Cambridge Institute Public Heatlh, England
-
- Leslie, R. D. (author)
- Queen Mary University of London, England
-
- Pozzilli, P. (author)
- University of Campus Biomed, Italy Queen Mary University of London, England
-
show less...
-
(creator_code:org_t)
- 2013-10-29
- 2014
- English.
-
In: Diabetes, obesity and metabolism. - : Wiley. - 1462-8902 .- 1463-1326. ; 16:3, s. 262-267
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- AimsC-peptide secretion is currently the only available clinical biomarker to measure residual -cell function in type 1 diabetes. However, the natural history of C-peptide decline after diagnosis can vary considerably dependent upon several variables. We investigated the shape of C-peptide decline over time from type 1 diabetes onset in relation to age at diagnosis, haemoglobin A1c (HbA1c) levels and insulin dose. MethodsWe analysed data from 3929 type 1 diabetes patients recruited from seven European centres representing all age groups at disease onset (childhood, adolescence and adulthood). The influence of the age at onset on -cell function was investigated in a longitudinal analysis at diagnosis and up to 5-years follow-up. ResultsFasting C-peptide (FCP) data at diagnosis were available in 3668 patients stratified according to age at diagnosis in four groups (less than5years, n=344; greater than5yearsless than10years, n=668; greater than10yearsless than18years, n=991; greater than18years, n=1655). FCP levels were positively correlated with age (pless than0.001); the subsequent decline in FCP over time was log-linear with a greater decline rate in younger age groups (pless than0.0001). ConclusionsThis study reveals a positive correlation between age at diagnosis of type 1 diabetes and FCP with a more rapid decline of -cell function in the very young patients. These data can inform the design of clinical trials using C-peptide values as an end-point for the effect of a given treatment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- beta cell; clinical trial; type 1 diabetes
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Barker, A.
-
Lauria, A.
-
Schloot, N.
-
Hosszufalusi, N.
-
Ludvigsson, John ...
-
Mathieu, C.
-
show more...
-
Mauricio, D.
-
Nordwall, Maria
-
Van der Schueren ...
-
Mandrup-Poulsen, ...
-
Scherbaum, W .A.
-
Weets, I.
-
Gorus, F. K.
-
Wareham, N.
-
Leslie, R. D.
-
Pozzilli, P.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
- Articles in the publication
-
Diabetes, obesit ...
- By the university
-
Linköping University