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  • Lazarevic, VladimirLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden Lund University, Sweden (author)

Incidence and prognostic significance of karyotypic subgroups in older patients with acute myeloid leukemia: the Swedish population-based experience

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • 2014-02-28
  • London, United Kingdom :Nature Publishing Group: Open Access Journals - Option B / Nature Publishing Group,2014
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-105903
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-105903URI
  • https://doi.org/10.1038/bcj.2014.10DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-37790URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-87882URI
  • https://lup.lub.lu.se/record/4384309URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:128468249URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-222944URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agency:Swedish Cancer Society
  • The Swedish population-based acute myeloid leukemia registry contains data from 3251 patients (excluding acute promyelocytic leukemia) diagnosed between 1997 and 2006. Informative cytogenetic data from 1893 patients were retrospectively added, including 1054 patients aged between 60 and 79 years. Clonal abnormalities were found in 57% of the informative karyotypes. Karyotypic patterns differed by age: t(8; 21), inv(16) and t(11q23) were more common in younger patients, whereas loss of 5q, 7q and 17p, monosomal karyotype (MK) and complex karyotypes were more common in older patients. Loss of 5q, 7q and 17p often occurred together within MK. Patients with greater than= 5 chromosome abnormalities had worse overall survival than those with fewer abnormalities or normal karyotype in all age groups. Loss of 5q, 7q and/or 17p had, in contrast to MK, a further negative impact on survival. Multivariable Cox regression analyses on risk factors in patients less than80 years with cytogenetic abnormalities and intensive treatment revealed that age and performance status had the most significant impact on survival (both Pless than0.001), followed by sex (P = 0.0135) and a karyotype including - 7/del(7q) (P = 0.048).

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hörstedt, Ann-sofiLund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital, Sweden(Swepub:lu)med-afh (author)
  • Johansson, BertilLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,University of and Regional Labs Regional Skåne, Sweden Lund University, Sweden(Swepub:lu)kgen-bjo (author)
  • Antunovic, PetarLinköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Department of Hematology, Linköping University Hospital, Linköping, Sweden(Swepub:liu)petan27 (author)
  • Billstrom, R.Department of Medicine, Central Hospital Skövde, Skövde, Sweden (author)
  • Derolf, A.Karolinska Institutet,Karolinska University Hospital, Sweden Karolinska University Hospital, Sweden (author)
  • Hulegardh, E.Department of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden (author)
  • Lehmann, S.Karolinska Institutet,Karolinska University Hospital, Sweden Karolinska University Hospital, Sweden (author)
  • Mollgard, L.Department of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden (author)
  • Nilsson, C.Karolinska Institutet,Karolinska University Hospital, Sweden Karolinska University Hospital, Sweden (author)
  • Peterson, StefanLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital, Sweden(Swepub:lu)med-sfp (author)
  • Stockelberg, D.Department of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden (author)
  • Uggla, Bertil,1962-Region Örebro län,Department of Medicine, Örebro University Hospital, Örebro, Sweden(Swepub:oru)bua (author)
  • Wennstrom, L.Department of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden (author)
  • Wahlin, AndersUmeå universitet,Onkologi,Umeå University, Sweden(Swepub:umu)anwa0027 (author)
  • Höglund, MartinUppsala universitet,Hematologi,Academic Hospital, Sweden(Swepub:uu)martinhl (author)
  • Juliusson, GunnarLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden Lund University, Sweden(Swepub:lu)stem-gju (author)
  • Stamcellscentrum (SCC)Avdelningen för stamcellsforskning (creator_code:org_t)

Related titles

  • In:Blood Cancer JournalLondon, United Kingdom : Nature Publishing Group: Open Access Journals - Option B / Nature Publishing Group4:e1882044-5385

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