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Season of infectiou...
Season of infectious mononucleosis and risk of multiple sclerosis at different latitudes; the EnvIMS Study
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- Lossius, Andreas (author)
- University of Oslo, Norway National Hospital Norway, Norway
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- Riise, Trond (author)
- University of Bergen, Norway
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- Pugliatti, Maura (author)
- University of Bergen, Norway University of Sassari, Italy
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- Bjornevik, Kjetil (author)
- University of Bergen, Norway
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- Casetta, Ilaria (author)
- University of Ferrara, Italy
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- Drulovic, Jelena (author)
- University of Belgrade, Serbia
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- Granieri, Enrico (author)
- University of Ferrara, Italy
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- Kampman, Margitta T. (author)
- University of Tromso, Norway University Hospital North Norway, Norway
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- Landtblom, Anne-Marie (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för neurovetenskap,Hälsouniversitetet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Neurologiska kliniken,Medicinska specialistkliniken,Department of Clinical and Experimental Medicine, Linköping University, Sweden
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- Lauer, Klaus (author)
- Griesheim, Germany
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- Magalhaes, Sandra (author)
- McGill University, Canada
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- Myhr, Kjell-Morten (author)
- Haukeland Hospital, Norway University of Bergen, Norway
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- Pekmezovic, Tatjana (author)
- University of Belgrade, Serbia
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- Wesnes, Kristin (author)
- University of Bergen, Norway
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- Wolfson, Christina (author)
- McGill University, Canada McGill University, Canada
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- Holmoy, Trygve (author)
- University of Oslo, Norway Aker University Hospital, Norway
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(creator_code:org_t)
- 2013-09-26
- 2014
- English.
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In: Multiple Sclerosis Journal. - : SAGE Publications (UK and US). - 1352-4585 .- 1477-0970. ; 20:6, s. 669-674
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: Seasonal fluctuations in solar radiation and vitamin D levels could modulate the immune response against Epstein-Barr virus (EBV) infection and influence the subsequent risk of multiple sclerosis (MS). Methods: Altogether 1660 MS patients and 3050 controls from Norway and Italy participating in the multinational case-control study of Environmental Factors In Multiple Sclerosis (EnvIMS) reported season of past infectious mononucleosis (IM). Results: IM was generally reported more frequently in Norway (p=0.002), but was associated with MS to a similar degree in Norway (odds ratio (OR) 2.12, 95% confidence interval (CI) 1.64-2.73) and Italy (OR 1.72, 95% CI 1.17-2.52). For all participants, there was a higher reported frequency of IM during spring compared to fall (pless than0.0005). Stratified by season of IM, the ORs for MS were 1.58 in spring (95% CI 1.08-2.31), 2.26 in summer (95% CI 1.46-3.51), 2.86 in fall (95% CI 1.69-4.85) and 2.30 in winter (95% CI 1.45-3.66). Conclusions: IM is associated with MS independently of season, and the association is not stronger for IM during spring, when vitamin D levels reach nadir. The distribution of IM may point towards a correlation with solar radiation or other factors with a similar latitudinal and seasonal variation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- vitamin D; Epstein-Barr virus; latitude; interaction; Multiple sclerosis; seasons
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lossius, Andreas
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Riise, Trond
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Pugliatti, Maura
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Bjornevik, Kjeti ...
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Casetta, Ilaria
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Drulovic, Jelena
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Granieri, Enrico
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Kampman, Margitt ...
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Landtblom, Anne- ...
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Lauer, Klaus
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Magalhaes, Sandr ...
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Myhr, Kjell-Mort ...
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Pekmezovic, Tatj ...
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Wesnes, Kristin
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Wolfson, Christi ...
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Holmoy, Trygve
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Multiple Scleros ...
- By the university
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Linköping University
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Uppsala University