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Apoptins : selective anticancer agents

Rollano Penaloza, Oscar M. (author)
Linköpings universitet,Avdelningen för cellbiologi,Hälsouniversitetet,Instituto de Biologia Molecular y Biotecnologia, La Paz, Bolivia
Lewandowska, Magdalena (author)
Pomeranian Medical University, Szczecin, Poland
Stetefeld, Joerg (author)
University of Manitoba, Winnipeg, Canada
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Ossysek, Karolina (author)
Jagiellonian University, Krakow, Poland
Madej, Mariusz (author)
Jagiellonian University, Krakow, Poland
Bereta, Joanna (author)
Jagiellonian University, Krakow, Poland
Sobczak, Mateusz (author)
Jagiellonian University, Krakow, Poland
Shojaei, Shahla (author)
Shiraz University of Medical Sciences, Iran
Ghavami, Saeid (author)
University of Manitoba, Winnipeg, Canada and Shiraz University of Medical Sciences, Iran
Los, Marek Jan (author)
Linköpings universitet,Avdelningen för cellbiologi,Hälsouniversitetet,Pomeranian Medical University, Szczecin, Poland
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 (creator_code:org_t)
Elsevier BV, 2014
2014
English.
In: Trends in Molecular Medicine. - : Elsevier BV. - 1471-4914 .- 1471-499X. ; 20:9, s. 519-528
  • Research review (peer-reviewed)
Abstract Subject headings
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  • Therapies that selectively target cancer cells for deathhave been the center of intense research recently. Onepotential therapy may involve apoptin proteins, whichare able to induce apoptosis in cancer cells leavingnormal cells unharmed. Apoptin was originally discoveredin the Chicken anemia virus (CAV); however, humangyroviruses (HGyV) have recently been found that alsoharbor apoptin-like proteins. Although the cancer cellspecific activity of these apoptins appears to be wellconserved, the precise functions and mechanisms ofaction are yet to be fully elucidated. Strategies for bothdelivering apoptin to treat tumors and disseminating theprotein inside the tumor body are now being developed,and have shown promise in preclinical animal studies.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

anticancer agents; anaphase-promoting complex; CDK2; protein kinase C; protein phosphatase 2A.

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