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  • Imamura, TeruhikoUniversity of Tokyo, Japan (author)

Acute pulmonary vasoreactivity test with sildenafil or nitric monoxide before left ventricular assist device implantation

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2013-04-05
  • Springer Verlag (Germany),2013
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-111181
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-111181URI
  • https://doi.org/10.1007/s10047-013-0706-4DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • There has been no established medical therapy to ameliorate pulmonary hypertension (PH) owing to left heart disease (LHD-PH). It has recently been shown that the left ventricular assist device (LVAD) can improve LHD-PH and therefore has the potential to become a major bridge tool for heart transplantation (HTx). However, some patients still have persistent PH even after LVAD treatment. It is essential to demonstrate the reversibility of end-organ dysfunction, including PH, prior to implantable LVAD treatment, especially in Japan, because implantable LVAD treatment is indicated only as bridge to transplantation. Here we report a patient with LHD-PH whose PH was demonstrated to be reversible by the acute pulmonary vasoreactivity test (APVT) with nitrogen monoxide (NO) and the phosphodiesterase-5 inhibitor sildenafil. Both inhaled NO and sildenafil reduced pulmonary vascular resistance, but pulmonary capillary wedge pressure was increased by NO, which was conversely decreased under increased cardiac output by sildenafil. After the patient was listed as an HTx recipient, pulmonary vascular resistance recovered down to an acceptable range with LVAD treatment. Based on these findings, we suggest that the APVT with sildenafil may be a useful and safe tool to predict improvement of PH after LVAD treatment.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Kinugawa, KoichiroUniversity of Tokyo, Japan (author)
  • Hatano, MasaruUniversity of Tokyo, Japan (author)
  • Kato, NaokoUniversity of Tokyo, Japan(Swepub:liu)naope77 (author)
  • Minatsuki, ShunUniversity of Tokyo, Japan (author)
  • Muraoka, HironoriUniversity of Tokyo, Japan (author)
  • Inaba, ToshiroUniversity of Tokyo, Japan (author)
  • Maki, HisatakaUniversity of Tokyo, Japan (author)
  • Kimura, MitsutoshiUniversity of Tokyo, Japan (author)
  • Kinoshita, OsamuUniversity of Tokyo, Japan (author)
  • Shiga, TaroUniversity of Tokyo, Japan (author)
  • Yao, AtsushiUniversity of Tokyo, Japan (author)
  • Kyo, ShuneiUniversity of Tokyo, Japan (author)
  • Ono, MinoruUniversity of Tokyo, Japan (author)
  • Komuro, IsseiUniversity of Tokyo, Japan (author)
  • University of Tokyo, Japan (creator_code:org_t)

Related titles

  • In:Journal of Artificial Organs: Springer Verlag (Germany)16:3, s. 389-3921434-72291619-0904

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