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  • Imamura, TeruhikoUniversity of Tokyo, Japan (author)

Urine osmolality estimated using urine urea nitrogen, sodium and creatinine can effectively predict response to tolvaptan in decompensated heart failure patients

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • Japanese Circulation Society,2013
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-111184
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-111184URI
  • https://doi.org/10.1253/circj.CJ-12-1328DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Japan Society for the Promotion of Science [224943]; Japanese Heart Foundation; Japanese Association for Cerebro-Cardiovascular Disease Control; AstraZeneca; Pfizer Health Research Foundation
  • BACKGROUND:Urine osmolality (U-OSM) is valuable to predict response to tolvaptan (TLV) in decompensated heart failure patients, but measurement of U-OSM is not always available on site.METHODS AND RESULTS:Data were collected from 66 hospitalized patients with decompensated heart failure who had received TLV at 3.75-15 mg/day. U-OSM, which was estimated using the following formula: 1.07×{2×[(urine sodium (mEq/L)]+[urine urea nitrogen (mg/dl)]/2.8+[urine creatinine (mg/dl)]×2/3}+16, was well correlated with the actual measurement (r=0.938, P<0.001). Criteria consisting of C1 (estimated baseline U-OSM>358 mOsm/L) and C2 (%decrease in estimated U-OSM>24% at 4-6 h after the first TLV dose) significantly discriminated responders from non-responders (P<0.05).CONCLUSIONS:Response to TLV can be predicted using U-OSM, which can be estimated using urine urea nitrogen, sodium, and creatinine concentration data. 

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Kinugawa, KoichiroUniversity of Tokyo, Japan (author)
  • Minatsuki, ShunUniversity of Tokyo, Japan (author)
  • Muraoka, HironoriUniversity of Tokyo, Japan (author)
  • Kato, NaokoUniversity of Tokyo, Japan(Swepub:liu)naope77 (author)
  • Inaba, ToshiroUniversity of Tokyo, Japan (author)
  • Maki, HisatakaUniversity of Tokyo, Japan (author)
  • Shiga, TaroUniversity of Tokyo, Japan (author)
  • Hatano, MasaruUniversity of Tokyo, Japan (author)
  • Yao, AtsushiUniversity of Tokyo, Japan (author)
  • Kyo, ShuneiUniversity of Tokyo, Japan (author)
  • Komuro, IsseiUniversity of Tokyo, Japan (author)
  • University of Tokyo, Japan (creator_code:org_t)

Related titles

  • In:Circulation Journal: Japanese Circulation Society77:5, s. 1208-12131346-98431347-4820

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