Search: WFRF:(Jacobs David R. Jr) >
Lipophilic Environm...
Lipophilic Environmental Chemical Mixtures Released During Weight-Loss : The Need to Consider Dynamics
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- Lee, Duk-Hee (author)
- Kyungpook Natl Univ, Sch Med, Dept Prevent Med, Daegu 41944, South Korea.
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- Jacobs, David R., Jr. (author)
- Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN 55454 USA.
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- Lind, Lars (author)
- Uppsala universitet,Klinisk epidemiologi
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- Lind, P. Monica, 1957- (author)
- Uppsala universitet,Arbets- och miljömedicin
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Kyungpook Natl Univ, Sch Med, Dept Prevent Med, Daegu 41944, South Korea Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN 55454 USA. (creator_code:org_t)
- 2020-05-04
- 2020
- English.
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In: Bioessays. - : Wiley. - 0265-9247 .- 1521-1878. ; 42:6
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Intentional weight loss can increase health risk in the long-term, despite short-term benefits, because human adipose tissue is widely contaminated with various lipophilic environmental contaminants, especially persistent organic pollutants (POPs). Recently, chronic exposure to low POPs has emerged as a new risk factor for common metabolic diseases and cardiovascular diseases. The amount of POPs released from adipocytes to the circulation increases during weight loss, thereby increasing POPs exposure of other critical organs. Possible harmful effects due to release of POPs during weight loss are opposite to those usually expected from losing weight. It is speculated that this tradeoff can explain recent puzzling findings on intensive weight loss. The presence of POPs in adipose tissue adds a challenge to weight management and an optimal strategy of weight management needs to consider both fat mass and dynamics of POPs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- cardiovascular diseases
- diabetes
- obesity
- persistent organic pollutants
- weight loss
Publication and Content Type
- ref (subject category)
- art (subject category)
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