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Etiology of Childho...
Etiology of Childhood Diarrhea After Rotavirus Vaccine Introduction A Prospective, Population-based Study in Nicaragua
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- Becker-Dreps, Sylvia (författare)
- University of N Carolina, NC 27599 USA
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- Bucardo, Filemon (författare)
- National Autonomous University of Nicaragua, Nicaragua
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- Vilchez, Samuel (författare)
- National Autonomous University of Nicaragua, Nicaragua
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- Enrique Zambrana, Luis (författare)
- Centre Epidemiol and Health CIDS, Nicaragua
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- Liu, Lan (författare)
- University of N Carolina, NC USA
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- Weber, David J. (författare)
- University of N Carolina, NC 27599 USA
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- Pena, Rodolfo (författare)
- Centre Health Research CIS, Nicaragua
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- Barclay, Leslie (författare)
- Centre Disease Control and Prevent, GA USA
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- Vinje, Jan (författare)
- Centre Disease Control and Prevent, GA USA
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- Hudgens, Michael G. (författare)
- University of N Carolina, NC USA
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- Nordgren, Johan (författare)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet
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- Svensson, Lennart (författare)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet
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- Morgan, Douglas R. (författare)
- University of N Carolina, NC 27599 USA; Vanderbilt University, TN 37235 USA
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- Espinoza, Felix (författare)
- National Autonomous University of Nicaragua, Nicaragua
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- Paniagua, Margarita (författare)
- National Autonomous University of Nicaragua, Nicaragua
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(creator_code:org_t)
- Lippincott, Williams andamp; Wilkins, 2014
- 2014
- Engelska.
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Ingår i: The Pediatric Infectious Disease Journal. - : Lippincott, Williams andamp; Wilkins. - 0891-3668 .- 1532-0987. ; 33:11, s. 1156-1163
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: Nicaragua was the first developing nation to implement routine immunization with the pentavalent rotavirus vaccine (RV5). In this RV5-immunized population, understanding infectious etiologies of childhood diarrhea is necessary to direct diarrhea treatment and prevention efforts. Methods: We followed a population-based sample of children less than5 years in Leon, Nicaragua for diarrhea episodes through household visits. Information was obtained on RV5 history and sociodemographics. Stool samples collected during diarrhea episodes and among healthy children underwent laboratory analysis for viral, bacterial and parasitic enteropathogens. Detection frequency and incidence of each enteropathogen was calculated. Results: The 826 children in the cohort experienced 677 diarrhea episodes during 607.5 child-years of exposure time (1.1 episodes per child-year). At least 1 enteropathogen was detected among 61.1% of the 337 diarrheal stools collected. The most common enteropathogens among diarrheal stools were: norovirus (20.4%), sapovirus (16.6%), enteropathogenic Escherichia coli (11.3%), Entamoeba histolytica/dispar (8.3%), Giardia lamblia (8.0%) and enterotoxigenic E. coli (7.7%), with rotavirus detected among 5.3% of diarrheal stools. Enteropathogenic Escherichia coli and enterotoxigenic E. coli were frequently detected among stools from healthy children. Among children with diarrhea, norovirus was more commonly detected among younger children (less than2 years) and G. lamblia was more commonly detected among older children (2-4 years). The mean age of rotavirus detection was 34.6 months. Conclusions: In this Central American community after RV5 introduction, rotavirus was not commonly detected among children with diarrhea. Prevention and appropriate management of norovirus and sapovirus should be considered to further reduce the burden of diarrheal disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- childhood; community; diarrhea; Nicaragua; Rotavirus vaccine
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- ref (ämneskategori)
- art (ämneskategori)
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Becker-Dreps, Sy ...
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Bucardo, Filemon
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Vilchez, Samuel
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Enrique Zambrana ...
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Liu, Lan
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Weber, David J.
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visa fler...
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Pena, Rodolfo
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Barclay, Leslie
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Vinje, Jan
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Hudgens, Michael ...
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Nordgren, Johan
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Svensson, Lennar ...
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Morgan, Douglas ...
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Espinoza, Felix
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Paniagua, Margar ...
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