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Effect of Radiother...
Effect of Radiotherapy After Breast-Conserving Surgery for Ductal Carcinoma in Situ: 20 Years Follow-Up in the Randomized SweDCIS Trial
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- Wärnberg, Fredrik (author)
- Uppsala universitet,Endokrinkirurgi,Uppsala University, Sweden
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- Garmo, Hans (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Uppsala University, Sweden; Kings Coll London, England
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- Emdin, Stefan (author)
- Umeå University Hospital, Sweden
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- Hedberg, Veronica (author)
- Gavle Central Hospital, Sweden
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- Adwall, Linda (author)
- Uppsala universitet,Endokrinkirurgi,Uppsala University, Sweden
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- Sandelin, Kerstin (author)
- Karolinska Institutet
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- Ringberg, Anita (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital, Sweden; Lund University, Sweden
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- Karlsson, Per (author)
- Sahlgrens University Hospital, Sweden
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- Arnesson, Lars-Gunnar (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Kirurgiska kliniken US
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- Anderson, Harald (author)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden
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- Jirström, Karin (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden
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- Holmberg, Lars (author)
- Uppsala universitet,Uppsala University,Endokrinkirurgi,Uppsala University, Sweden; Kings Coll London, England
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(creator_code:org_t)
- American Society of Clinical Oncology, 2014
- 2014
- English.
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In: Journal of Clinical Oncology. - : American Society of Clinical Oncology. - 0732-183X .- 1527-7755. ; 32:32, s. 3613-
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Abstract
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- Purpose Four randomized studies show that adjuvant radiotherapy (RT) lowers the risk of subsequent ipsilateral breast events (IBEs) after breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS) by approximately 50% after 10 to 15 years. We present 20 years of follow-up data for the SweDCIS trial. Patients and Methods Between 1987 and 1999 1,046 women were randomly assigned to RT or not after BCS for primary DCIS. Results up to 2005 have been published, and we now add another 7 years of follow-up. All breast cancer events and causes of death were registered. Results There were 129 in situ and 129 invasive IBEs. Absolute risk reduction in the RT arm was 12.0% at 20 years (95% CI, 6.5 to 17.7), with a relative risk reduction of 37.5%. Absolute reduction was 10.0% (95% CI, 6.0 to 14.0) for in situ and 2.0% (95% CI, -3.0 to 7.0) for invasive IBEs. There was a nonstatistically significantly increased number of contralateral events in the RT arm (67 v 48 events; hazard ratio, 1.38; 95% CI, 0.95 to 2.00). Breast cancer-specific death and overall survival were not influenced. Younger women experienced a relatively higher risk of invasive IBE and lower effect of RT. The hazard over time looked different for in situ and invasive IBEs. Conclusion Use of adjuvant RT is supported by 20-year follow-up. Modest protection against invasive recurrences and a possible increase in contralateral cancers still call for a need to find groups of patients for whom RT could be avoided or mastectomy with breast reconstruction is indicated.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Wärnberg, Fredri ...
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Garmo, Hans
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Emdin, Stefan
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Hedberg, Veronic ...
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Adwall, Linda
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Sandelin, Kersti ...
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show more...
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Ringberg, Anita
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Karlsson, Per
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Arnesson, Lars-G ...
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Anderson, Harald
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Jirström, Karin
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Holmberg, Lars
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Journal of Clini ...
- By the university
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Linköping University
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Umeå University
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Lund University
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Uppsala University
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Karolinska Institutet