Placental immune response to apple allergen in allergic mothers

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Abelius, MartinaLinköpings universitet,Avdelningen för inflammationsmedicin,Hälsouniversitetet (författare)

Placental immune response to apple allergen in allergic mothers

Artikel/kapitelEngelska2014

Förlag, utgivningsår, omfång ...

Elsevier,2014
electronicrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:liu-113184
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-113184URI
https://doi.org/10.1016/j.jri.2014.05.001DOI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

Funding Agencies|Institut Danone (Haar, Germany); European Network of Excellence within the 6th Framework Programme of the European Union [512040]; Swedish Research Council [K2011-56X-21854-01-06]; Cancer and Allergy Association; Olle Engkvist Foundation
The immunological milieu in the placenta may be crucial for priming the developing foetal immune system. Early imbalances may promote the establishment of immune-mediated diseases in later life, including allergies. The initial exposure to allergens seems to occur in utero, but little is known about allergen-induced placental cytokine and chemokine release. The release of several cytokines and chemokines from placenta tissue after exposure to mast cell degranulator compound 48/80 or apple allergen in placentas from allergic and healthy mothers was to be analysed. Four placentas from women with apple allergy and three controls were applied in a placental perfusion model with two separate cotyledons simultaneously perfused with and without apple allergen (Mal d 1). Two control placentas were perfused with compound 48/80. In outflow, histamine was quantified spectrophotofluorometrically, IL-2, IL-4, IL-6, IL-10, TNF and IFN-gamma by a cytometric multiplex bead array and IL-13 and CXCL10, CXCL11, CCL17 and CCL22 with an in-house multiplex Luminex assay. Compound 48/80 induced a rapid release of histamine, CXCL10, CXCL11, CCL17 and CCL22, but not of the other factors. Apple allergen induced a time-dependent release of IL-6 and TNF, but not of histamine, in placentas of women with apple allergy compared with the unstimulated cotyledon. CCL17 levels were slightly increased after allergen stimulation in control placentas. Allergens can induce placental cytokines and chemokines distinctly in allergic and healthy mothers. These mediators may affect the prenatal development of the immune system and modify the risk of diseases related to immune disorders in childhood such as allergies.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
Allergy; Chemokines; Cytokines; Ex vivo placental perfusion; Histamine; Placenta

Biuppslag (personer, institutioner, konferenser, titlar ...)

Enke, UtaUniversity Hospital Jena, Germany (författare)
Varosi, FraukeUniversity Hospital Jena, Germany (författare)
Hoyer, HeikeUniversity Hospital Jena, Germany (författare)
Schleussner, EkkehardUniversity Hospital Jena, Germany (författare)
Jenmalm, MariaLinköpings universitet,Avdelningen för inflammationsmedicin,Hälsouniversitetet(Swepub:liu)marje18 (författare)
Markert, Udo R.University Hospital Jena, Germany (författare)
Linköpings universitetAvdelningen för inflammationsmedicin (creator_code:org_t)

Sammanhörande titlar

Ingår i:Journal of Reproductive Immunology: Elsevier106, s. 100-1090165-03781872-7603

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Av författaren/redakt...: Abelius, Martina; Enke, Uta; Varosi, Frauke; Hoyer, Heike; Schleussner, Ekk ...; Jenmalm, Maria; visa fler...; Markert, Udo R.; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin

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Av lärosätet: Linköpings universitet

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