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- Gustafsson, HåkanÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för radiologiska vetenskaper,Hälsouniversitetet,Medicinsk teknik i Östergötland,Centrum för medicinsk bildvetenskap och visualisering, CMIV,CMIV (author)
Visualization of oxidative stress in ex vivo biopsies using electron paramagnetic resonance imaging
- Article/chapterEnglish2015
Publisher, publication year, extent ...
- 2014-04-18
- Wiley,2015
- electronicrdacarrier
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- LIBRIS-ID:oai:DiVA.org:liu-113407
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-113407URI
- https://doi.org/10.1002/mrm.25267DOI
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- Language:English
- Summary in:English
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- PURPOSE: The purpose of this study was to develop an X-Band electron paramagnetic resonance imaging protocol for visualization of oxidative stress in biopsies.METHODS: The developed electron paramagnetic resonance imaging protocol was based on spin trapping with the cyclic hydroxylamine spin probe 1-hydroxy-3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine and X-Band EPR imaging. Computer software was developed for deconvolution and back-projection of the EPR image. A phantom containing radicals of known spatial characteristic was used for evaluation of the developed protocol. As a demonstration of the technique electron paramagnetic resonance imaging of oxidative stress was performed in six sections of atherosclerotic plaques. Histopathological analyses were performed on adjoining sections.RESULTS: The developed computer software for deconvolution and back-projection of the EPR images could accurately reproduce the shape of a phantom of known spatial distribution of radicals. The developed protocol could successfully be used to image oxidative stress in six sections of the three ex vivo atherosclerotic plaques.CONCLUSIONS: We have shown that oxidative stress can be imaged using a combination of spin trapping with the cyclic hydroxylamine spin probe cyclic hydroxylamine spin probe 1-hydroxy-3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine and X-Band EPR imaging. A thorough and systematic evaluation on different types of biopsies must be performed in the future to validate the proposed technique. Magn Reson Med, 2014.
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- Hallbeck, MartinLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Klinisk patologi och klinisk genetik(Swepub:liu)marha90 (author)
- Lindgren, MikaelLinköpings universitet,Kemi,Tekniska högskolan,Norwegian University of Science and Technology, Norway(Swepub:liu)mikli67 (author)
- Kolbun, NatalliaLinköpings universitet,Avdelningen för radiologiska vetenskaper,Hälsouniversitetet,Centrum för medicinsk bildvetenskap och visualisering, CMIV(Swepub:liu)natko13 (author)
- Jonson, MariaLinköpings universitet,Kemi,Tekniska högskolan (author)
- Engström, MariaLinköpings universitet,Avdelningen för radiologiska vetenskaper,Hälsouniversitetet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,CMIV(Swepub:liu)maren21 (author)
- de Muinck, EboLinköpings universitet,Hälsouniversitetet,Avdelningen för kardiovaskulär medicin,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)ebode21 (author)
- Zachrisson, HeleneLinköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Region Östergötland, Fysiologiska kliniken US(Swepub:liu)helza09 (author)
- Linköpings universitetAvdelningen för radiologiska vetenskaper (creator_code:org_t)
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- In:Magnetic Resonance in Medicine: Wiley73:4, s. 1682-16910740-31941522-2594
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