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A population-based ...
A population-based study of cervical carcinoma and HPV infection in Latvia.
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- Silins, Ilvars (author)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups,Oncology Center of Latvia, Riga, Latvia / Department of Gynecologic Oncology, Radiumhemmet, Karolinska Hospital, Stockholm, Sweden / Department of Medical Microbiology, MAS University Hospital, Malmö, Sweden
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- Wang, Xiaodong (author)
- Lund University,Lunds universitet,Linköpings universitet,Fysik och elektroteknik,Tekniska högskolan,Department of Medical Microbiology, MAS University Hospital, Malmö, Sweden,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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- Tadesse, Amha (author)
- Merck Research Laboratories, West Point, PA 19486, USA
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- Jansen, Kathrin U (author)
- Merck Research Laboratories, West Point, PA 19486, USA
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- Schiller, John T (author)
- Laboratory of Cellular Oncology, The National Cancer Institute, Bethesda, MD 20892, USA
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- Åvall-Lundqvist, Elisabeth (author)
- Karolinska Institutet,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Department of Gynecologic Oncology, Radiumhemmet, Karolinska Hospital, Stockholm, Sweden
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- Frankendal, Bo (author)
- Department of Gynecologic Oncology, Radiumhemmet, Karolinska Hospital, Stockholm, Sweden
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- Dillner, Joakim (author)
- Karolinska Institutet,Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups,Department of Medical Microbiology, MAS University Hospital, Malmö, Sweden
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(creator_code:org_t)
- Academic Press, 2004
- 2004
- English.
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In: Gynecologic Oncology. - : Academic Press. - 0090-8258 .- 1095-6859. ; 93:2, s. 484-492
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- OBJECTIVES: We wished to quantify the population-based importance of cervical carcinoma risk factors in Latvia.METHODS: Totally, 223 of 224 eligible cases of incident invasive cervical carcinoma were enrolled during July 1998-February 2001 in Latvia. An age-matched sample of 300 healthy control women was selected from the Latvian population registry and 239 of these women (79%) were enrolled. A demographic and life-style questionnaire was completed, cervical brush samples were analyzed for human papillomavirus (HPV) DNA by PCR and serum samples for HPV antibodies.RESULTS: Risk factors for cervical cancer in multivariate analysis were HPV type 16 or 18 DNA positivity (OR = 32.4; CI 95% 16.5-63.6) and living in the capital (OR = 2.4; CI 95% 1.2-4.7). Oral contraceptive use was not a risk factor (OR = 0.4; CI 95% 0.2-1.1). A strong protective effect was found for having had more than three Pap smears in the last 5 years (OR = 0.07 CI 95% 0.03-0.19).CONCLUSIONS: Inadequate population coverage of Pap smears, in spite of excessive smear usage, caused 28.4% of cervical cancers in age groups eligible for screening. HPV type 16 infection was the most important risk factor for cervical cancer in Latvia, with a population-attributable risk percent for all ages of 58.5%.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Cervical cancer
- Epidemiology
- HPV infection
- Screening
Publication and Content Type
- ref (subject category)
- art (subject category)
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