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Four-month metacarp...
Four-month metacarpal bone mineral density loss predicts radiological joint damage progression after 1 year in patients with early rheumatoid arthritis: exploratory analyses from the IMPROVED study
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- Wevers-de Boer, K. V. C. (author)
- LUMC, Netherlands
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- Heimans, L. (author)
- LUMC, Netherlands
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- Visser, K. (author)
- LUMC, Netherlands
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- Kälvesten, Johan (author)
- Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Sectra, Linkoping, Sweden
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- Goekoop, R. J. (author)
- Haga Hospital, Netherlands
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- van Oosterhout, M. (author)
- Groene Hart Hospital, Netherlands
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- Harbers, J. B. (author)
- Franciscus Hospital, Netherlands
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- Bijkerk, C. (author)
- Reinier Graaf Gasthuis, Netherlands
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- Steup-Beekman, M. (author)
- Bronovo Hospital, Netherlands
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- de Buck, M. P. D. M. (author)
- MCH, Netherlands
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- de Sonnaville, P. B. J. (author)
- Oosterschelde Hospital, Netherlands
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- Huizinga, T. W. J. (author)
- LUMC, Netherlands
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- Allaart, C. F. (author)
- LUMC, Netherlands
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(creator_code:org_t)
- 2013-11-27
- 2015
- English.
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In: Annals of the Rheumatic Diseases. - : BMJ Publishing Group. - 0003-4967 .- 1468-2060. ; 74:2, s. 341-346
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Aim To assess whether in early (rheumatoid) arthritis (RA) patients, metacarpal bone mineral density (BMD) loss after 4 months predicts radiological progression after 1 year of antirheumatic treatment. Methods Metacarpal BMD was measured 4 monthly during the first year by digital X-ray radiogrammetry (DXR-BMD) in patients participating in the IMPROVED study, a clinical trial in 610 patients with recent onset RA (2010 criteria) or undifferentiated arthritis, treated according to a remission (disease activity scoreless than1.6) steered strategy. With Sharp/van der Heijde progression greater than= 0.5 points after 1 year (yes/no) as dependent variable, univariate and multivariate logistic regression analyses were performed. Results Of 428 patients with DXR-BMD results and progression scores available, 28 (7%) had radiological progression after 1 year. Independent predictors for radiological progression were presence of baseline erosions (OR (95% CI) 6.5 (1.7 to 25)) and early DXR-BMD loss (OR (95% CI) 1.5 (1.1 to 2.0)). In 366 (86%) patients without baseline erosions, early DXR-BMD loss was the only independent predictor of progression (OR (95% CI) 2.0 (1.4 to 2.9)). Conclusions In early RA patients, metacarpal BMD loss after 4 months of treatment is an independent predictor of radiological progression after 1 year. In patients without baseline erosions, early metacarpal BMD loss is the main predictor of radiological progression.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Wevers-de Boer, ...
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Heimans, L.
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Visser, K.
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Kälvesten, Johan
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Goekoop, R. J.
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van Oosterhout, ...
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show more...
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Harbers, J. B.
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Bijkerk, C.
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Steup-Beekman, M ...
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de Buck, M. P. D ...
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de Sonnaville, P ...
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Huizinga, T. W. ...
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Allaart, C. F.
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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Annals of the Rh ...
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Linköping University