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Severe infusion-rel...
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Norin, StefanKarolinska Institutet
(författare)
Severe infusion-related reactions are uncommon in rituximab-treated CLL patients in clinical practice: Results from a Swedish national observational study
- Artikel/kapitelEngelska2015
Förlag, utgivningsår, omfång ...
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Elsevier,2015
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-114250
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-114250URI
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https://doi.org/10.1016/j.leukres.2014.09.019DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:130480623URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies|Roche Sweden AB [ML22754]
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There have been concerns about serious infusion-related adverse drug reactions (ADR) with rituximabin chronic lymphocytic leukemia (CLL). We therefore conducted an observational trial in which CLL patients planned for rituximab-containing therapy were eligible. Ninety-six patients from 19 centers were enrolled. The most common regimen was rituximab, fludarabine and cyclophosphamide. Fifty-six patients experienced ADR during rituximab infusion. Reactions greater than= grade 3 occurred in five patients and no cases of tumor lysis syndrome were recorded. Despite a high number of circulating tumor cells few severe ADR were noted. Thus, rituximab containing regimens can be considered safe for CLL patients in general practice.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Bjorkstrand, BoKarolinska University Hospital, Sweden; Karolinska Institute, Sweden
(författare)
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Rommel, FranzRegion Östergötland, Hematologiska kliniken US
(författare)
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Timberg, LarsKristianstad Central Hospital, Sweden
(författare)
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Andersson, Per-OlaSahlgrens University Hospital, Sweden
(författare)
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Haggstrom, JohanKalmar Hospital, Sweden
(författare)
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Aldrin, AndersVisby Hospital, Sweden
(författare)
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Hansson, LottaKarolinska Institutet
(författare)
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Karolinska InstitutetKarolinska University Hospital, Sweden; Karolinska Institute, Sweden
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Leukemia Research: Elsevier39:1, s. 33-370145-21261873-5835
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