Search: WFRF:(Nordquist Lina) >
Activation of Hypox...
Activation of Hypoxia-Inducible Factors Prevents Diabetic Nephropathy
-
- Nordquist, Lina (author)
- Uppsala universitet,Integrativ Fysiologi,Uppsala University, Sweden
-
- Friederich-Persson, Malou (author)
- Uppsala universitet,Integrativ Fysiologi,Uppsala University, Sweden
-
- Fasching, Angelica (author)
- Uppsala universitet,Integrativ Fysiologi,Uppsala University, Sweden
-
show more...
-
- Liss, Per (author)
- Uppsala universitet,Enheten för radiologi,Uppsala University, Sweden
-
- Shoji, Kumi (author)
- University of Tokyo, Japan
-
- Nangaku, Masaomi (author)
- University of Tokyo, Japan
-
- Hansell, Peter (author)
- Uppsala universitet,Integrativ Fysiologi,Uppsala University, Sweden
-
- Palm, Fredrik (author)
- Uppsala universitet,Linköpings universitet,Avdelningen för läkemedelsforskning,Hälsouniversitetet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Uppsala University, Sweden,Integrativ Fysiologi
-
show less...
-
(creator_code:org_t)
- American Society of Nephrology, 2015
- 2015
- English.
-
In: Journal of the American Society of Nephrology. - : American Society of Nephrology. - 1046-6673 .- 1533-3450. ; 26:2, s. 328-338
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Hyperglycemia results in increased oxygen consumption and decreased oxygen tension in the kidney. We tested the hypothesis that activation of hypoxia-inducible factors (HIFs) protects against diabetes-induced alterations in oxygen metabolism and kidney function. Experimental groups consisted of control and streptozotocin-induced diabetic rats treated with or without chronic cobalt chloride to activate HIFs. We elucidated the involvement of oxidative stress by studying the effects of acute administration of the superoxide dismutase mimetic tempol. Compared with controls, diabetic rats displayed tissue hypoxia throughout the kidney, glonnerular hyperfiltration, increased oxygen consumption, increased total mitochondrial leak respiration, and decreased tubular sodium transport efficiency. Diabetic kidneys showed proteinuria and tubulointerstitial damage. Cobalt chloride activated HIFs, prevented the diabetes-induced alterations in oxygen metabolism, mitochondrial leak respiration, and kidney function, and reduced proteinuria and tubulointerstitial damage. The beneficial effects of tempol were less pronounced after activation of HIFs, indicating improved oxidative stress status. In conclusion, activation of HIFs prevents diabetes-induced alteration in kidney oxygen metabolism by normalizing glomerular filtration, which reduces tubular electrolyte load, preventing mitochondrial leak respiration and improving tubular transport efficiency. These improvements could be related to reduced oxidative stress and account for the reduced proteinuria and tubulointerstitial damage. Thus, pharnnacologic activation of the HIF system may prevent development of diabetic nephropathy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database