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BMI is an important...
BMI is an important driver of beta-cell loss in type 1 diabetes upon diagnosis in 10 to 18-year-old children
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- Lauria, A. (author)
- University of Campus Biomed, Italy
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- Barker, A. (author)
- MRC Epidemiol Unit, England
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- Schloot, N. (author)
- University of Dusseldorf, Germany
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- Hosszufalusi, N. (author)
- Semmelweis Univ, Hungary
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- Ludvigsson, Johnny (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Barn- och ungdomskliniken i Linköping,Medicinska fakulteten
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- Mathieu, C. (author)
- Katholieke University of Leuven, Belgium
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- Mauricio, D. (author)
- Hospital Arnau Vilanova, Spain
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- Nordwall, Maria (author)
- Linköpings universitet,Östergötlands Läns Landsting,Barn- och ungdomskliniken i Norrköping,Avdelningen för kliniska vetenskaper,Medicinska fakulteten
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- Van der Schueren, B. (author)
- Katholieke University of Leuven, Belgium
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- Mandrup-Poulsen, T. (author)
- University of Copenhagen, Denmark; Karolinska Institute, Sweden
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- Scherbaum, W. A. (author)
- University of Dusseldorf, Germany
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- Weets, I. (author)
- VUB, Belgium; VUB, Belgium; BDR, Belgium
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- Gorus, F. K. (author)
- VUB, Belgium; VUB, Belgium; BDR, Belgium
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- Wareham, N. (author)
- MRC Epidemiol Unit, England
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- Leslie, R. D. (author)
- Queen Mary University of London, England
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- Pozzilli, P. (author)
- University of Campus Biomed, Italy; Queen Mary University of London, England
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(creator_code:org_t)
- BioScientifica, 2015
- 2015
- English.
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In: European Journal of Endocrinology. - : BioScientifica. - 0804-4643 .- 1479-683X. ; 172:2, s. 107-113
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objective: Body weight-related insulin resistance probably plays a role in progression to type 1 diabetes, but has an uncertain impact following diagnosis. In this study, we investigated whether BMI measured at diagnosis was an independent predictor of C-peptide decline 1-year post-diagnosis. Design: Multicentre longitudinal study carried out at diagnosis and up to 1-year follow-up. Methods: Data on C-peptide were collected from seven diabetes centres in Europe. Patients were grouped according to age at diagnosis (less than5 years, n = 126; greater than5 years less than10 years, n = 295; greater than10 years less than18 years, n = 421; greater than18 years, n = 410). Linear regression was used to investigate whether BMI was an independent predictor of change in fasting C-peptide over 1 year. Models were additionally adjusted for baseline insulin dose and HbA1c. Results: In individuals diagnosed between 0 and 5 years, 5 and 10 years and those diagnosed greater than18 years, we found no association between BMI and C-peptide decline. In patients aged 10-18 years, higher BMI at baseline was associated with a greater decline in fasting C-peptide over 1 year with a decrease (beta 95% CI; P value) of 0.025 (0.010, 0.041) nM/kg per m(2) higher baseline BMI (P = 0.001). This association remained significant after adjusting for gender and differences in HbA1c and insulin dose (beta = 0.026, 95% CI = 0.0097, 0.042; P = 0.002). Conclusions: These observations indicate that increased body weight and increased insulin demand are associated with more rapid disease progression after diagnosis of type 1 diabetes in an age group 10-18 years. This should be considered in studies of beta-cell function in type 1 diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Lauria, A.
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Barker, A.
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Schloot, N.
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Hosszufalusi, N.
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Ludvigsson, John ...
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Mathieu, C.
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Mauricio, D.
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Nordwall, Maria
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Van der Schueren ...
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Mandrup-Poulsen, ...
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Scherbaum, W. A.
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Weets, I.
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Gorus, F. K.
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Wareham, N.
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Leslie, R. D.
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Pozzilli, P.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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European Journal ...
- By the university
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Linköping University
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Karolinska Institutet