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Body size and the r...
Body size and the risk of multiple sclerosis in Norway and Italy : The EnvIMS study.
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- Wesnes, Kristin (author)
- University of Bergen/The Norwegian MS Competence Centre, Haukeland University Hospital, Norway
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- Riise, Trond (author)
- University of Bergen/The Norwegian MS Competence Centre, Haukeland University Hospital, Norway
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- Casetta, Ilaria (author)
- Section of Clinical Neurology, University of Ferrara, Italy
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- Drulovic, Jelena (author)
- Clinic of Neurology, Faculty of Medicine, University of Belgrade, Serbia
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- Granieri, Enrico (author)
- Section of Clinical Neurology, University of Ferrara, Italy
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- Holmøy, Trygve (author)
- Institute of Clinical Medicine, Faculty of Medicine, University of Oslo/Akershus University Hospital, Norway
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- Kampman, Margitta T (author)
- University of Tromsø/University Hospital of North Norway, Norway
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- Landtblom, Anne-Marie (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Hälsouniversitetet,Neurologiska kliniken,Division of Neurology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
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- Lauer, Klaus (author)
- Darmstadt, Germany
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- Lossius, Andreas (author)
- Institute of Clinical Medicine, Faculty of Medicine, University of Oslo/Institute of Immunology, Oslo University
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- Magalhaes, Sandra (author)
- Department of Epidemiology and Biostatistics and occupational health, McGill University, Montreal, Canada
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- Pekmezovic, Tatjana (author)
- Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Serbia
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- Bjørnevik, Kjetil (author)
- University of Bergen/The Norwegian MS Competence Centre, Haukeland University Hospital, Norway
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- Wolfson, Christina (author)
- Research institute of the McGill University Health Centre, Montreal, Canada
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- Pugliatti, Maura (author)
- University of Bergen, Norway/ Department of Clinical and Experimental Medicine, University of Sassari, Italy
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- Myhr, Kjell-Morten (author)
- The Norwegian MS Competence Centre, Haukeland University Hospital/The KG Jebsen Centre for MS-Research, University of Bergen, Norway
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(creator_code:org_t)
- 2014-09-02
- 2015
- English.
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In: Multiple Sclerosis Journal. - : SAGE Publications. - 1352-4585 .- 1477-0970. ; 21:4, s. 388-395
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- BACKGROUND: Obesity may be a risk factor for developing multiple sclerosis (MS).OBJECTIVE: We examined if body size influences the risk of MS in a population-based, case control study.METHODS: A total of 953 cases and 1717 controls from Norway and 707 cases and 1333 controls from Italy reported their body size by choosing a silhouette 1 to 9 (largest) every fifth year from age 5 to 30 and at time of study. The body size-related MS risk was defined by odds ratios (ORs) in logistic regression analyses adjusting for age, smoking and outdoor activity.RESULTS: In Norway a large body size (silhouettes 6-9) compared to silhouette 3 increased the risk of MS, especially at age 25 (OR 2.21; 95% CI 1.09-4.46 for men and OR 1.43; 95% CI 0.90-2.27 for women). When comparing silhouette 9 to 1, we found a significant dose-response from age 10 until age 30 peaking at age 25 (sex-adjusted OR 2.83; 95% CI 1.68-4.78). The association was present for at least 15 years prior to disease onset. No significant associations were found in Italy.CONCLUSIONS: Obesity from childhood until young adulthood is a likely risk factor for MS with a seemingly stronger effect in Norway than in Italy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Multiple sclerosis; body mass index; body size; case control studies; epidemiology; obesity; vitamin D
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Wesnes, Kristin
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Riise, Trond
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Casetta, Ilaria
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Drulovic, Jelena
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Granieri, Enrico
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Holmøy, Trygve
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Kampman, Margitt ...
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Landtblom, Anne- ...
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Lauer, Klaus
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Lossius, Andreas
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Magalhaes, Sandr ...
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Pekmezovic, Tatj ...
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Bjørnevik, Kjeti ...
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Wolfson, Christi ...
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Pugliatti, Maura
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Myhr, Kjell-Mort ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Multiple Scleros ...
- By the university
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Linköping University
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Uppsala University