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Body size and the risk of multiple sclerosis in Norway and Italy : The EnvIMS study.

Wesnes, Kristin (författare)
University of Bergen/The Norwegian MS Competence Centre, Haukeland University Hospital, Norway
Riise, Trond (författare)
University of Bergen/The Norwegian MS Competence Centre, Haukeland University Hospital, Norway
Casetta, Ilaria (författare)
Section of Clinical Neurology, University of Ferrara, Italy
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Drulovic, Jelena (författare)
Clinic of Neurology, Faculty of Medicine, University of Belgrade, Serbia
Granieri, Enrico (författare)
Section of Clinical Neurology, University of Ferrara, Italy
Holmøy, Trygve (författare)
Institute of Clinical Medicine, Faculty of Medicine, University of Oslo/Akershus University Hospital, Norway
Kampman, Margitta T (författare)
University of Tromsø/University Hospital of North Norway, Norway
Landtblom, Anne-Marie (författare)
Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Hälsouniversitetet,Neurologiska kliniken,Division of Neurology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
Lauer, Klaus (författare)
Darmstadt, Germany
Lossius, Andreas (författare)
Institute of Clinical Medicine, Faculty of Medicine, University of Oslo/Institute of Immunology, Oslo University
Magalhaes, Sandra (författare)
Department of Epidemiology and Biostatistics and occupational health, McGill University, Montreal, Canada
Pekmezovic, Tatjana (författare)
Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Serbia
Bjørnevik, Kjetil (författare)
University of Bergen/The Norwegian MS Competence Centre, Haukeland University Hospital, Norway
Wolfson, Christina (författare)
Research institute of the McGill University Health Centre, Montreal, Canada
Pugliatti, Maura (författare)
University of Bergen, Norway/ Department of Clinical and Experimental Medicine, University of Sassari, Italy
Myhr, Kjell-Morten (författare)
The Norwegian MS Competence Centre, Haukeland University Hospital/The KG Jebsen Centre for MS-Research, University of Bergen, Norway
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 (creator_code:org_t)
2014-09-02
2015
Engelska.
Ingår i: Multiple Sclerosis Journal. - : SAGE Publications. - 1352-4585 .- 1477-0970. ; 21:4, s. 388-395
Relaterad länk:
https://doi.org/10.1...
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https://urn.kb.se/re...
https://doi.org/10.1...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BACKGROUND: Obesity may be a risk factor for developing multiple sclerosis (MS).OBJECTIVE: We examined if body size influences the risk of MS in a population-based, case control study.METHODS: A total of 953 cases and 1717 controls from Norway and 707 cases and 1333 controls from Italy reported their body size by choosing a silhouette 1 to 9 (largest) every fifth year from age 5 to 30 and at time of study. The body size-related MS risk was defined by odds ratios (ORs) in logistic regression analyses adjusting for age, smoking and outdoor activity.RESULTS: In Norway a large body size (silhouettes 6-9) compared to silhouette 3 increased the risk of MS, especially at age 25 (OR 2.21; 95% CI 1.09-4.46 for men and OR 1.43; 95% CI 0.90-2.27 for women). When comparing silhouette 9 to 1, we found a significant dose-response from age 10 until age 30 peaking at age 25 (sex-adjusted OR 2.83; 95% CI 1.68-4.78). The association was present for at least 15 years prior to disease onset. No significant associations were found in Italy.CONCLUSIONS: Obesity from childhood until young adulthood is a likely risk factor for MS with a seemingly stronger effect in Norway than in Italy.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

Multiple sclerosis; body mass index; body size; case control studies; epidemiology; obesity; vitamin D

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