Early Psychosocial Exposures, Hair Cortisol Levels, and Disease Risk

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Karlén, JerkerLinköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten (author)

Early Psychosocial Exposures, Hair Cortisol Levels, and Disease Risk

Article/chapterEnglish2015

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2015-06-01
American Academy of Pediatrics,2015
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LIBRIS-ID:oai:DiVA.org:liu-119795
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-119795URI
https://doi.org/10.1542/peds.2014-2561DOI

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Language:English
Summary in:English

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Funding Agencies|Swedish Child Diabetes Foundation (Barndiabetesfonden); Research Council of Southeast Sweden [FORSS-87771, FORSS-36321]; Swedish Medical Research Council [K99-72X-11242-05A]; Wallenberg Foundation [K 98-99D-12813-01A]; County Council of Ostergotland project grant, Linkoping, Sweden
BACKGROUND: Early psychosocial exposures are increasingly recognized as being crucial to health throughout life. A possible mechanism could be physiologic dysregulation due to stress. Cortisol in hair is a new biomarker assessing long-term hypothalamic-pituitary-adrenal axis activity. The objective was to investigate whether early-life adverse psychosocial circumstances influence infant cortisol levels in hair and health outcomes in children prospectively until age 10. METHODS: A cohort study in the general community using a questionnaire covering 11 psychosocial items in the family during pregnancy and the cumulative incidence of diagnoses until age 10 years in 1876 children. Cortisol levels in hair were measured by using a radioimmunoassay in those with sufficient hair samples at age 1, yielding a subsample of n = 209. RESULTS: Children with added psychosocial exposures had higher infant cortisol levels in hair (B = 0.40, P less than .0001, adjusted for gender and size for gestational age) in a cumulative manner and were significantly more often affected by 12 of the 14 most common childhood diseases, with a general pattern of increasing odds ratios. CONCLUSIONS: The findings support the model of physiologic dysregulation as a plausible mechanism by which the duration and number of early detrimental psychosocial exposures determine health outcomes. The model indicates that the multiplicity of adversities should be targeted in future interventions and could help to identify children who are at high risk of poor health. Furthermore, given the prolonged nature of exposure to a stressful social environment, the novel biomarker of cortisol in hair could be of major importance.

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Ludvigsson, JohnnyLinköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Barn- och ungdomskliniken i Linköping(Swepub:liu)johlu29 (author)
Hedmark, MaxLinköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten (author)
Olsen Faresjö, ÅshildLinköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten(Swepub:liu)asols47 (author)
Theodorsson, ElvarLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Region Östergötland, Klinisk kemi(Swepub:liu)elvth65 (author)
Faresjö, TomasLinköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten(Swepub:liu)tomfa28 (author)
Linköpings universitetAvdelningen för samhällsmedicin (creator_code:org_t)

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In:Pediatrics: American Academy of Pediatrics135:6, s. E1450-E14570031-40051098-4275

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