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  • Slind Olsen, RenateLinköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,County Hospital Ryhov, Sweden,University of Linköping (author)

CD93 gene polymorphism is associated with disseminated colorectal cancer

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • 2015-05-26
  • Springer Verlag (Germany),2015
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-120141
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-120141URI
  • https://doi.org/10.1007/s00384-015-2247-1DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-26756URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Foundation of Clinical Cancer Research, Jonkoping [110426-1]; Futurum; Academy of Healthcare; County Council of Jonkoping [FUTURUM-105891]; FORSS, the Research Council of Southeastern Sweden [FORSS-373251]
  • Cluster of differentiation 93 (CD93) is involved in apoptosis and inflammation and has a suggested role in angiogenesis, and all of which are involved in the development and dissemination of cancer. We evaluated the expression of CD93 and the association with two single nucleotide polymorphisms (SNPs), rs2749812 and rs2749817, as possible biomarkers in colorectal cancer (CRC). Tissue levels and plasma levels of CD93 were measured using an enzyme-linked immunosorbent assay (ELISA). Expression of CD93 was determined by immunohistochemistry, western blot and gene expression analysis. Genotype frequencies were established for the SNPs by real-time polymerase chain reaction (PCR), and the association with tumour stage and survival was analysed. Total CD93 levels were 82 % higher (P less than 0.001) in tumours compared to matched normal tissues. Mean levels of soluble CD93 in plasma were 30 % lower (P less than 0.001) in the patients compared to the controls. The T/T genotype of SNP rs2749817 was more common in stage IV patients, with consequently higher risk of CRC death (T/T vs. C/C and C/T; hazard ratio (HR) = 1.73, 95 % confidence interval (CI) = 1.11-2.67, P = 0.014), and was associated with a higher risk of CRC recurrence after radical operation (T/T vs. C/C and C/T; HR = 2.07, CI = 1.22-3.51, P = 0.007). We showed that the T/T genotype of SNP rs2749817 is associated with disseminated cancer at diagnosis and an increased recurrence rate after radical operation. Patients with this genotype may benefit from early identification.

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  • Lindh, MikaelCounty Hospital Ryhov, Jönköping, Sweden (author)
  • Vorkapic, EminaLinköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,University of Linköping(Swepub:liu)emivo27 (author)
  • Andersson, Roland E.County Hospital Ryhov, Jönköping, Sweden (author)
  • Zar, NiklasCounty Hospital Ryhov, Jönköping, Sweden (author)
  • Lofgren, StureCounty Hospital Ryhov, Jönköping, Sweden (author)
  • Dimberg, JanJönköping University,HHJ, Avdelningen för naturvetenskap och biomedicin,HHJ. Biomedicinsk plattform (author)
  • Matussek, AndreasCounty Hospital Ryhov, Jönköping, Sweden (author)
  • Wågsäter, DickLinköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,University of Linköping(Swepub:liu)dicwa60 (author)
  • Linköpings universitetAvdelningen för läkemedelsforskning (creator_code:org_t)

Related titles

  • In:International Journal of Colorectal Disease: Springer Verlag (Germany)30:7, s. 883-8900179-19581432-1262

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