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  • Ballester, FacundoUniversity of Valencia, Spain (author)

A generic high-dose rate Ir-192 brachytherapy source for evaluation of model-based dose calculations beyond the TG-43 formalism

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • 2015-05-27
  • American Association of Physicists in Medicine: Medical Physics,2015
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-120661
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-120661URI
  • https://doi.org/10.1118/1.4921020DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Purpose: In order to facilitate a smooth transition for brachytherapy dose calculations from the American Association of Physicists in Medicine (AAPM) Task Group No. 43 (TG-43) formalism to model-based dose calculation algorithms (MBDCAs), treatment planning systems (TPSs) using a MBDCA require a set of well-defined test case plans characterized by Monte Carlo (MC) methods. This also permits direct dose comparison to TG-43 reference data. Such test case plans should be made available for use in the software commissioning process performed by clinical end users. To this end, a hypothetical, generic high-dose rate (HDR) Ir-192 source and a virtual water phantom were designed, which can be imported into a TPS. Methods: A hypothetical, generic HDR Ir-192 source was designed based on commercially available sources as well as a virtual, cubic water phantom that can be imported into any TPS in DICOM format. The dose distribution of the generic Ir-192 source when placed at the center of the cubic phantom, and away from the center under altered scatter conditions, was evaluated using two commercial MBDCAs [Oncentra (R) Brachy with advanced collapsed-cone engine (ACE) and BrachyVision AcuRos (TM)]. Dose comparisons were performed using state-of-the-art MC codes for radiation transport, including ALGEBRA, BrachyDose, GEANT4, MCNP5, MCNP6, and pENELopE2008. The methodologies adhered to recommendations in the AAPM TG-229 report on high-energy brachytherapy source dosimetry. TG-43 dosimetry parameters, an along-away dose-rate table, and primary and scatter separated (PSS) data were obtained. The virtual water phantom of (201)(3) voxels (1 mm sides) was used to evaluate the calculated dose distributions. Two test case plans involving a single position of the generic HDR Ir-192 source in this phantom were prepared: (i) source centered in the phantom and (ii) source displaced 7 cm laterally from the center. Datasets were independently produced by different investigators. MC results were then compared against dose calculated using TG-43 and MBDCA methods. Results: TG-43 and PSS datasets were generated for the generic source, the PSS data for use with the ACE algorithm. The dose-rate constant values obtained from seven MC simulations, performed independently using different codes, were in excellent agreement, yielding an average of 1.1109 +/- 0.0004 cGy/(h U) (k = 1, Type A uncertainty). MC calculated dose-rate distributions for the two plans were also found to be in excellent agreement, with differences within type A uncertainties. Differences between commercial MBDCA and MC results were test, position, and calculation parameter dependent. On average, however, these differences were within 1% for ACUROS and 2% for ACE at clinically relevant distances. Conclusions: A hypothetical, generic HDR Ir-192 source was designed and implemented in two commercially available TPSs employing different MBDCAs. Reference dose distributions for this source were benchmarked and used for the evaluation of MBDCA calculations employing a virtual, cubic water phantom in the form of a CT DICOM image series. The implementation of a generic source of identical design in all TPSs using MBDCAs is an important step toward supporting univocal commissioning procedures and direct comparisons between TPSs. (C) 2015 American Association of Physicists in Medicine.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Carlsson Tedgren, ÅsaLinköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Region Östergötland, Radiofysikavdelningen US,Karolinska University Hospital, Sweden(Swepub:liu)asaca90 (author)
  • Granero, DomingoHospital Gen University, Spain (author)
  • Haworth, AnnettePeter MacCallum Cancer Centre, Australia; RMIT University, Australia (author)
  • Mourtada, FirasHelen F Graham Cancer Centre, DE 19713 USA (author)
  • Paiva Fonseca, GabrielCNEN SP, Brazil; Maastricht University, Netherlands (author)
  • Zourari, KyveliUniversity of Athens, Greece (author)
  • Papagiannis, PanagiotisUniversity of Athens, Greece (author)
  • Rivard, Mark J.Tufts University, MA 02111 USA (author)
  • Siebert, Frank-AndreUniversity Hospital Schleswig Holstein, Germany (author)
  • Sloboda, Ron S.Cross Cancer Institute, Canada; University of Alberta, Canada (author)
  • Smith, Ryan L.Alfred Hospital, Australia (author)
  • Thomson, Rowan M.Carleton University, Canada (author)
  • Verhaegen, FrankMaastricht University, Netherlands; McGill University, Canada (author)
  • Vijande, JavierUniversity of Valencia, Spain; IFIC CSIC UV, Spain (author)
  • Ma, YunzhiCHU Quebec, Canada; University of Laval, Canada; University of Laval, Canada (author)
  • Beaulieu, LucCHU Quebec, Canada; University of Laval, Canada; University of Laval, Canada (author)
  • University of Valencia, SpainAvdelningen för radiologiska vetenskaper (creator_code:org_t)

Related titles

  • In:Medical physics (Lancaster): American Association of Physicists in Medicine: Medical Physics42:6, s. 3048-30620094-2405

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