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Influence on Deep B...
Influence on Deep Brain Stimulation from Lead Design, Operating Mode and Tissue Impedance Changes – A Simulation Study
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- Alonso, Fabiola, 1980- (författare)
- Linköpings universitet,Biomedicinsk instrumentteknik,Tekniska fakulteten,MINT
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- Hemm-Ode, Simone (författare)
- Linköpings universitet,Biomedicinsk instrumentteknik,Tekniska högskolan,University of Applied Sciences and Arts Northwestern Switzerland,MINT
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- Wårdell, Karin (författare)
- Linköpings universitet,Biomedicinsk instrumentteknik,Tekniska fakulteten,MINT
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(creator_code:org_t)
- Los Angeles, CA, USA : Omics Publishing Group, 2015
- 2015
- Engelska.
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Ingår i: Brain Disorders and Therapy. - Los Angeles, CA, USA : Omics Publishing Group. - 2168-975X. ; 4:3
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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visa fler...
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https://urn.kb.se/re...
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https://doi.org/10.4...
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Abstract
Ämnesord
Stäng
- Background: Deep brain stimulation (DBS) systems in current mode and new lead designs are recently available. To switch between DBS-systems remains complicated as clinicians may lose their reference for programming. Simulations can help increase the understanding.Objective: To quantitatively investigate the electric field (EF) around two lead designs simulated to operate in voltage and current mode under two time points following implantation.Methods: The finite element method was used to model Lead 3389 (Medtronic) and 6148 (St Jude) with homogenous surrounding grey matter and a peri-electrode space (PES) of 250 μm. The PES-impedance mimicked the acute (extracellular fluid) and chronic (fibrous tissue) time-point. Simulations at different amplitudes of voltage and current (n=236) were performed using two different contacts. Equivalent current amplitudes were extracted by matching the shape and maximum EF of the 0.2 V/mm isolevel.Results: The maximum EF extension at 0.2 V/mm varied between 2-5 mm with a small difference between the leads. In voltage mode EF increased about 1 mm at acute compared to the chronic PES. Current mode presented the opposite relationship. Equivalent EFs for lead 3389 at 3 V were found for 7 mA (acute) and 2.2 mA (chronic).Conclusions: Simulations showed a major impact on the electric field extension between postoperative time points. This may explain the clinical decisions to reprogram the amplitude weeks after implantation. Neither the EF extension nor intensity is considerably influenced by the lead design.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Elektroteknik och elektronik -- Annan elektroteknik och elektronik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Electrical Engineering, Electronic Engineering, Information Engineering -- Other Electrical Engineering, Electronic Engineering, Information Engineering (hsv//eng)
Nyckelord
- deep brain stimulation (DBS)
- voltage and current stimulation
- finite element method
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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