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  • Onengut-Gumuscu, SunaCenter for Public Health Genomics, Univ Department of Medicine, Division of Endocrinology, University of Virginia, Charlottesville, Virginia, USA (författare)

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.

  • Artikel/kapitelEngelska2015

Förlag, utgivningsår, omfång ...

  • 2015-03-09
  • Springer Science and Business Media LLC,2015
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-121132
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-121132URI
  • https://doi.org/10.1038/ng.3245DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:131041575URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Genetic studies of type 1 diabetes (T1D) have identified 50 susceptibility regions, finding major pathways contributing to risk, with some loci shared across immune disorders. To make genetic comparisons across autoimmune disorders as informative as possible, a dense genotyping array, the Immunochip, was developed, from which we identified four new T1D-associated regions (P < 5 × 10(-8)). A comparative analysis with 15 immune diseases showed that T1D is more similar genetically to other autoantibody-positive diseases, significantly most similar to juvenile idiopathic arthritis and significantly least similar to ulcerative colitis, and provided support for three additional new T1D risk loci. Using a Bayesian approach, we defined credible sets for the T1D-associated SNPs. The associated SNPs localized to enhancer sequences active in thymus, T and B cells, and CD34(+) stem cells. Enhancer-promoter interactions can now be analyzed in these cell types to identify which particular genes and regulatory sequences are causal.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Chen, Wei-MinCenter for Public Health Genomics, Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, Virginia, USA (författare)
  • Burren, OliverJuvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK (författare)
  • Cooper, Nick JJuvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK (författare)
  • Quinlan, Aaron RCenter for Public Health Genomics, Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, Virginia, USA (författare)
  • Mychaleckyj, Josyf CCenter for Public Health Genomics, Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, Virginia, USA (författare)
  • Farber, EmilyCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA (författare)
  • Bonnie, Jessica KCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA (författare)
  • Szpak, MichalCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA (författare)
  • Schofield, EllenJuvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK (författare)
  • Achuthan, PremanandJuvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK (författare)
  • Guo, HuiJuvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK (författare)
  • Fortune, Mary DJuvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK (författare)
  • Stevens, HelenJuvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK (författare)
  • Walker, Neil MJuvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK (författare)
  • Ward, Lucas DDepartment of Computer Science, Massachusetts Institute of Technology (MIT), Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA (författare)
  • Kundaje, AnshulDepartment of Computer Science, Massachusetts Institute of Technology (MIT), Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA / Department of Genetics, Stanford University, Stanford, California, USA / Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA (författare)
  • Kellis, ManolisDepartment of Computer Science, Massachusetts Institute of Technology (MIT), Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA (författare)
  • Daly, Mark JBroad Institute of MIT and Harvard, Cambridge, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA (författare)
  • Barrett, Jeffrey CWellcome Trust Sanger Institute, Hinxton, UK (författare)
  • Cooper, Jason DJuvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK (författare)
  • Deloukas, PanosWellcome Trust Sanger Institute, Hinxton, UK (författare)
  • Todd, John AJuvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK (författare)
  • Wallace, ChrisJuvenile Diabetes Research Foundation (JDRF)/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Medical Research Council (MRC) Biostatistics Unit, Institute of Public Health, University Forvie Site, Cambridge, UK (författare)
  • Concannon, PatrickCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA (författare)
  • Rich, Stephen SCenter for Public Health Genomics, University of Virginia, Department of Public Health Sciences, Division of Biostatistics and Epidemiology, Charlottesville, Virginia, USA (författare)
  • Ludvigsson, JohnnyLinköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten(Swepub:liu)johlu29 (bidragsgivare)
  • Center for Public Health Genomics, Univ Department of Medicine, Division of Endocrinology, University of Virginia, Charlottesville, Virginia, USACenter for Public Health Genomics, Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, Virginia, USA (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Nature Genetics: Springer Science and Business Media LLC47:4, s. 381-3861061-40361546-1718

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