Sökning: (WFRF:(Hammarström Per)) srt2:(2015-2019)
> (2015) >
Porcine prion prote...
Porcine prion protein amyloid
-
- Hammarström, Per (författare)
- Linköpings universitet,Kemi,Tekniska fakulteten
-
- Nyström, Sofie (författare)
- Linköpings universitet,Kemi,Tekniska fakulteten
-
(creator_code:org_t)
- 2015-07-28
- 2015
- Engelska.
-
Ingår i: Prion. - : Taylor andamp; Francis: STM, Behavioural Science and Public Health Titles. - 1933-6896 .- 1933-690X. ; 9:4, s. 266-277
- Relaterad länk:
-
https://www.tandfonl...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Mammalian prions are composed of misfolded aggregated prion protein (PrP) with amyloid-like features. Prions are zoonotic disease agents that infect a wide variety of mammalian species including humans. Mammals and by-products thereof which are frequently encountered in daily life are most important for human health. It is established that bovine prions (BSE) can infect humans while there is no such evidence for any other prion susceptible species in the human food chain (sheep, goat, elk, deer) and largely prion resistant species (pig) or susceptible and resistant pets (cat and dogs, respectively). PrPs from these species have been characterized using biochemistry, biophysics and neurobiology. Recently we studied PrPs from several mammals in vitro and found evidence for generic amyloidogenicity as well as cross-seeding fibril formation activity of all PrPs on the human PrP sequence regardless if the original species was resistant or susceptible to prion disease. Porcine PrP amyloidogenicity was among the studied. Experimentally inoculated pigs as well as transgenic mouse lines overexpressing porcine PrP have, in the past, been used to investigate the possibility of prion transmission in pigs. The pig is a species with extraordinarily wide use within human daily life with over a billion pigs harvested for human consumption each year. Here we discuss the possibility that the largely prion disease resistant pig can be a clinically silent carrier of replicating prions.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Nyckelord
- prion; pig; amyloid fibril; misfolding; transmissibility; seeding; TSE; prion strain; strain adaptation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Prion
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas