SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Aguilera Maria)
 

Sökning: WFRF:(Aguilera Maria) > (2015-2019) > Increased humoral i...

  • Vicario, MariaVall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain; Centre Invest Biomed Red Enfermedades Hepat and Digest, Spain (författare)

Increased humoral immunity in the jejunum of diarrhoea-predominant irritable bowel syndrome associated with clinical manifestations

  • Artikel/kapitelEngelska2015

Förlag, utgivningsår, omfång ...

  • 2014-09-10
  • BMJ PUBLISHING GROUP,2015
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-121427
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-121427URI
  • https://doi.org/10.1136/gutjnl-2013-306236DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|Fondo de Investigacion Sanitaria; CIBERehd, Instituto de Salud Carlos III, Subdireccion General de Investigacion Sanitaria, Ministerio de Economia y Competitividad [CP10/00502, PI13/00935, CM08/00229, CM10/00155, FI12/00254, PI12/00314, EII2011-0035, PI11/00716]; Ministerio de Educacion, Direccion General de Investigacion [SAF 2009-07416]; Agencia de Gestio dAjuts Universitaris i de Recerca, de la Generalitat de Catalunya [2009 SGR 219, 2011 BP/A00099]; Rome Foundation; Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas [CB06/04/0021]
  • Background and aims Altered intestinal barrier is associated with immune activation and clinical symptoms in diarrhoea-predominant IBS (IBS-D). Increased mucosal antigen load may induce specific responses; however, local antibody production and its contribution to IBS aetiopathogenesis remain undefined. This study evaluated the role of humoral activity in IBS-D. Methods A single mucosal jejunal biopsy, luminal content and blood were obtained from healthy volunteers (H; n = 30) and IBS-D (n = 49; Rome III criteria) participants. Intraepithelial lymphocytes, mast cells, B lymphocytes and plasma cells were studied by imaging techniques. Differential gene expression and pathway analysis were assessed by microarray and PCR techniques. Blood and luminal immunoglobulins (Igs) were quantified. Gastrointestinal symptoms, respiratory atopy and stress and depression were also recorded. Results Patients with IBS-D showed a higher number and activation of mucosal B lymphocytes and plasma cells (p less than 0.05). Mast cell density was increased in patients with IBS-D (non-atopic) and in close proximity to plasma cells (p less than 0.05). Microarray profiling identified differential humoral activity in IBS-D, involving proliferation and activation of B lymphocytes and Igs production (p less than 0.001). Mucosal humoral activity was higher in IBS-D, with upregulation of germline transcripts and Ig genes (1.3-fold-1.7-fold increase; p less than 0.05), and increased IgG(+) cells and luminal IgG compared with H (p less than 0.05), with no differences in blood. Biological markers of humoral activity correlated positively with bowel movements, stool form and depression. Conclusions Enhanced small bowel humoral immunity is a distinctive feature of IBS-D. Mucosal Ig production contributes to local inflammation and clinical manifestations in IBS-D.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Gonzalez-Castro, Ana M.Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain (författare)
  • Martinez, CristinaHeidelberg University, Germany (författare)
  • Lobo, BeatrizVall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain (författare)
  • Pigrau, MarcVall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain (författare)
  • Guilarte, MarUniversity of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain (författare)
  • de Torres, InesUniversity of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain (författare)
  • Mosquera, Jose L.University of Barcelona, Spain (författare)
  • Fortea, MarinaVall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain (författare)
  • Sevillano-Aguilera, CesarVall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain (författare)
  • Salvo-Romero, EloisaVall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain (författare)
  • Alonso, CarmenVall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain; Centre Invest Biomed Red Enfermedades Hepat and Digest, Spain (författare)
  • Rodino-Janeiro, Bruno K.Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain (författare)
  • Söderholm, Johan D.Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US(Swepub:liu)sodda63 (författare)
  • Azpiroz, FernandoVall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain; Centre Invest Biomed Red Enfermedades Hepat and Digest, Spain (författare)
  • Santos, JavierVall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain; Centre Invest Biomed Red Enfermedades Hepat and Digest, Spain (författare)
  • Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain; Centre Invest Biomed Red Enfermedades Hepat and Digest, SpainVall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Gut: BMJ PUBLISHING GROUP64:9, s. 1379-13880017-57491468-3288

Internetlänk

Hitta via bibliotek

  • Gut (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy