A role for inflammatory metabolites as modulators of the glutamate N-methyl-D-aspartate receptor in depression and suicidality

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: L773:0889 1591 OR L773:1090 2139 OR L773:2666 3546 > A role for inflamma...

Details
MARC

Bay-Richter, CecilieLund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Aarhus University, Denmark (author)

A role for inflammatory metabolites as modulators of the glutamate N-methyl-D-aspartate receptor in depression and suicidality

Article/chapterEnglish2015

Publisher, publication year, extent ...

ACADEMIC PRESS INC ELSEVIER SCIENCE,2015
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:liu-121771
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-121771URI
https://doi.org/10.1016/j.bbi.2014.07.012DOI
https://lup.lub.lu.se/record/4614563URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:131952759URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Funding Agencies|Michigan State University; Van Andel Research Institute; Swedish Research Council [2009-4284, 2011-4787, 2002-5297, 2008-2922, 2009-7052, 2013-2838]; Province of Scania clinical state grants (ALF); Australian Research Council; National Health and Medical Research Council, Australia
Background: Patients with depression and suicidality suffer from low-grade neuroinflammation. Proinflammatory cytokines activate indoleamine 2,3-dioxygenase, an initial enzyme of the kynurenine pathway. This pathway produces neuroactive metabolites, including quinolinic- and kynurenic acid, binding to the glutamate N-methyl-D-aspartate-receptor, which is hypothesized to be part of the neural mechanisms underlying symptoms of depression. We therefore hypothesized that symptoms of depression and suicidality would fluctuate over time in patients prone to suicidal behavior, depending on the degree of inflammation and kynurenine metabolite levels in the cerebrospinal fluid (CSF). Methods: We measured cytokines and kynurenine metabolites in CSF, collected from suicide attempters at repeated occasions over 2 years (total patient samples n = 143, individuals n = 30) and healthy controls (n = 36). The association between the markers and psychiatric symptoms was assessed using the Montgomery Asberg Depression Rating Scale and the Suicide Assessment Scale. Results: Quinolinic acid was increased and kynurenic acid decreased over time in suicidal patients versus healthy controls. Furthermore, we found a significant association between low kynurenic acid and severe depressive symptoms, as well as between high interleukin-6 levels and more severe suicidal symptoms. Conclusions: We demonstrate a long-term dysregulation of the kynurenine pathway in the central nervous system of suicide attempters. An increased load of inflammatory cytokines was coupled to more severe symptoms. We therefore suggest that patients with a dysregulated kynurenine pathway are vulnerable to develop depressive symptoms upon inflammatory conditions, as a result the excess production of the NMDA-receptor agonist quinolinic acid. This study provides a neurobiological framework supporting the use of NMDA-receptor antagonists in the treatment of suicidality and depression. (C) 2014 Elsevier Inc. All rights reserved.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
Suicide; Glutamate; Quinolinic acid; Kynurenic acid; Interleukin-6; Cerebrospinal fluid

Added entries (persons, corporate bodies, meetings, titles ...)

Linderholm, Klas R.Karolinska Institute, Sweden (author)
Lim, Chai K.Macquarie University, Australia (author)
Samuelsson, MartinLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken(Swepub:liu)marsa78 (author)
Träskman Bendz, LilLund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden(Swepub:lu)psyk-lt8 (author)
Guillemin, Gilles J.Macquarie University, Australia (author)
Erhardt, SophieKarolinska Institutet,Karolinska Institute, Sweden (author)
Brundin, LenaLund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Michigan State University, MI USA; Van Andel Research Institute, MI USA(Swepub:lu)mphy-lla (author)
Psykiatri, LundSektion IV (creator_code:org_t)

Related titles

In:Brain, behavior, and immunity: ACADEMIC PRESS INC ELSEVIER SCIENCE43, s. 110-1170889-15911090-2139

Internet link

Find in a library

Brain, behavior, and immunity (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Bay-Richter, Cec ...; Linderholm, Klas ...; Lim, Chai K.; Samuelsson, Mart ...; Träskman Bendz, ...; Guillemin, Gille ...; show more...; Erhardt, Sophie; Brundin, Lena; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

Articles in the publication: Brain, behavior, ...

By the university: Linköping University; Lund University; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se