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Sökning: WFRF:(Sjöwall Johanna) > Hepatocyte growth f...

  • Ramezani, AmirRegion Östergötland, Neurokirurgiska kliniken US (författare)

Hepatocyte growth factor in cerebrospinal fluid differentiates community-acquired or nosocomial septic meningitis from other causes of pleocytosis

  • Artikel/kapitelEngelska2015

Förlag, utgivningsår, omfång ...

  • 2015-09-25
  • Springer Science and Business Media LLC,2015
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-122242
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-122242URI
  • https://doi.org/10.1186/s12987-015-0020-zDOI
  • https://lup.lub.lu.se/record/8034917URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND: Due to anatomical restrictions, the inflammatory response to intracerebral bacterial infections exposes swollen brain tissues to pressure and ischemia, resulting in life-threatening damage. Rapid diagnosis and immediate empirical antibiotic therapy is highly important. However, diagnosing meningitis in patients after neurosurgery is complicated, due to brain tissue damage and changes in cerebrospinal fluid (CSF) caused by surgery. Hepatocyte growth factor (HGF) is a local, acute-phase protein with healing properties. Previous studies on community-acquired septic meningitis reported high levels of intrathecally produced HGF. The present study focused on nosocomial meningitis in assessing the levels of HGF in the CSF.METHODS: HGF concentrations (ELISA) and HGF binding to receptors; c-Met receptor and heparan sulfate proteoglycan were determined in CSF samples (surface plasmon resonance). CSF samples from patients with community-acquired or nosocomial meningitis (217 samples from 135 patients) were compared to those from controls without signs of cerebral nervous system involvement (N = 36) and patients with Alzheimer's disease (N = 20).RESULTS: Compared to samples from patients that had undergone neurosurgery and had other infectious diseases, CSF samples from patients with nosocomial meningitis had significantly higher HGF concentrations (p < 0.001) and binding affinity to c-Met (p < 0.001) and HSPG (p = 0.043) receptors. The sensitivity and specificity to identify nosocomial septic meningitis were 69.7 and 93.4 %, respectively. The HGF concentration and binding affinity to HGF receptors were significantly higher in CSF from patients with community-acquired septic meningitis compared to patients with aseptic (viral and subacute) meningitis as well as controls (p < 0.001). The sensitivity and specificity to identify community-acquired septic meningitis were 95.4 and 95.7 %, respectively.DISCUSSION: In febrile nosocomial infections that occurred post neurosurgery, HGF assessment could substantially improve the differentiation of meningitis from other infections and therefore might be a tool for rapid diagnosis, limiting injuries and guiding antibiotic therapy.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Nägga, KatarinaLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Department of Clinical Sciences Malmö, Lunds University, Malmö(Swepub:lu)med-kng (författare)
  • Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Department of Clinical Sciences Malmö, Lunds University, Malmö(Swepub:lu)mphy-ohn (författare)
  • Lönn, JohannaSchool of Health and Medical Sciences, Örebro University (författare)
  • Sjöwall, JohannaLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Region Östergötland, Infektionskliniken i Östergötland(Swepub:liu)johfo45 (författare)
  • Katoozian, FatemePEAS Institut, Linköping (författare)
  • Mansouri, SepahdarPEAS Institut, Linköping (författare)
  • Nayeri, FaribaLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Region Östergötland, Infektionskliniken i Östergötland,PEAS Institut, Linköping(Swepub:liu)farna60 (författare)
  • Region Östergötland, Neurokirurgiska kliniken USKlinisk minnesforskning (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Fluids and Barriers of the CNS: Springer Science and Business Media LLC12:12045-8118

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