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Protective properti...
Protective properties of lysozyme on β-amyloid pathology : implications for Alzheimer disease
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- Helmfors, Linda (author)
- Linköpings universitet,Molekylär Bioteknik,Tekniska fakulteten
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- Boman, Andrea (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Civitelli, Livia (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten
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- Nath, Sangeeta (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Sandin, Linnea (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Janefjord, Camilla (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten
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- McCann, Heather (author)
- Neuroscience Research Australia and University of New South Wales, Australia
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- Zetterberg, Henrik (author)
- Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, Sahlgrenska University Hospital, Mölndal, Sweden / UCL Institute of Neurology, Queen Square, London, United Kingdom
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- Blennow, Kaj (author)
- Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, Sahlgrenska University Hospital, Mölndal, Sweden
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- Halliday, Glenda (author)
- UCL Institute of Neurology, Queen Square, London, United Kingdom
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- Brorsson, Ann-Christin (author)
- Linköpings universitet,Molekylär Bioteknik,Tekniska fakulteten
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- Kågedal, Katarina (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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(creator_code:org_t)
- Elsevier, 2015
- 2015
- English.
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In: Neurobiology of Disease. - : Elsevier. - 0969-9961 .- 1095-953X. ; 83, s. 122-133
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https://doi.org/10.1...
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Abstract
Subject headings
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- The hallmarks of Alzheimer disease are amyloid-β plaques and neurofibrillary tangles accompanied by signs of neuroinflammation. Lysozyme is a major player in the innate immune system and has recently been shown to prevent the aggregation of amyloid-β1-40 in vitro. In this study we found that patients with Alzheimer disease have increased lysozyme levels in the cerebrospinal fluid and lysozyme co-localized with amyloid-β in plaques. In Drosophila neuronal co-expression of lysozyme and amyloid-β1-42 reduced the formation of soluble and insoluble amyloid-β species, prolonged survival and improved the activity of amyloid-β1-42 transgenic flies. This suggests that lysozyme levels rise in Alzheimer disease as a compensatory response to amyloid-β increases and aggregation. In support of this, in vitro aggregation assays revealed that lysozyme associates with amyloid-β1-42 and alters its aggregation pathway to counteract the formation of toxic amyloid-β species. Overall, these studies establish a protective role for lysozyme against amyloid-β associated toxicities and identify increased lysozyme in patients with Alzheimer disease. Therefore, lysozyme has potential as a new biomarker as well as a therapeutic target for Alzheimer disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- Lysozyme
- Biomarker
- Alzheimer disease
- Drosophila
- Aβ aggregation
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Helmfors, Linda
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Boman, Andrea
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Civitelli, Livia
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Nath, Sangeeta
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Sandin, Linnea
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Janefjord, Camil ...
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show more...
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McCann, Heather
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Zetterberg, Henr ...
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Blennow, Kaj
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Halliday, Glenda
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Brorsson, Ann-Ch ...
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Kågedal, Katarin ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
- Articles in the publication
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Neurobiology of ...
- By the university
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Linköping University